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PTP4A2 Antibody

  • 货号：
    CSB-PA137436
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA137436(PTP4A2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse brain tissue, Mouse heart tissue, Primary antibody: CSB-PA137436(PTP4A2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q12974
  • 基因名：
    PTP4A2
  • 别名：
    PTP4A2 antibody; PRL2 antibody; PTPCAAX2 antibody; BM-008 antibody; Protein tyrosine phosphatase type IVA 2 antibody; EC 3.1.3.48 antibody; HU-PP-1 antibody; OV-1 antibody; PTP(CAAXII) antibody; Protein-tyrosine phosphatase 4a2 antibody; Protein-tyrosine phosphatase of regenerating liver 2 antibody; PRL-2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human PTP4A2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.
  • 基因功能参考文献：
    1. identified a critical role for PRL2 phosphatase in the proliferation and survival of human AML cells. Further, we demonstrated that PRL2 is essential for the leukemogenic potential of AML1-ETO9a in vivo PMID: 28220038
    2. Our findings highlight the important role of miR-29c in regulating CRC EMT via GSK-3b/b-catenin signaling by targeting GNA13 and PTP4A and provide new insights into the metastatic basis of colorectal cancer PMID: 25193986
    3. PTP4A2 expression is correlated with overall survival in progestin receptor-positive breast carcinomas. PMID: 23568563
    4. Results suggest a model in which PRL-2 promotes cell migration and invasion through an ERK1/2-dependent signaling pathway. PMID: 21765462
    5. PRL-2 plays an important role in lung cancer and can be a biomarker of lung cancer, substituting for the function of other PRLs. PMID: 21993571
    6. Overexpression of the protein tyrosine phosphatase PRL-2 correlates with breast tumor formation and progression. PMID: 20841483
    7. Mouse pre-B-cells transfected with human PRL-2 had higher growth responses to Epo or IL-3, shorter cell cycle, less Epo requirement for survival, more cell migration, less cell adhesion, change to an immature cell morphology, & more Bmi-1 expression. PMID: 20226699
    8. PRL-2 can promote cell adhesion and invasion activity of human hepatocellular carcinoma cells. PMID: 17666324
    9. PRL-2 mRNA expression was not significantly higher in malignant compared to benign breast tissue. PMID: 16832410
    10. PRL-2 was expressed heavily in almost every tissue and cell type examined. Widespread expression of PRL-2 in multiple organ systems suggests an important functional role for these enzymes in normal tissue homeostasis. PMID: 16957164

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  • 亚细胞定位：
    Cell membrane. Early endosome. Cytoplasm.
  • 蛋白家族：
    Protein-tyrosine phosphatase family
  • 组织特异性：
    Ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus. Overexpressed in prostate tumor tissue.
  • 数据库链接：

    HGNC: 9635

    OMIM: 601584

    KEGG: hsa:8073

    STRING: 9606.ENSP00000344909

    UniGene: Hs.470477