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PTGER1 Antibody

  • 货号：
    CSB-PA005788
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HepG2 cells using EP1 Polyclonal Antibody.
  • 其他：

产品详情

  • Uniprot No.：
    P34995
  • 基因名：
  • 别名：
    PTGER1; Prostaglandin E2 receptor EP1 subtype; PGE receptor EP1 subtype; PGE2 receptor EP1 subtype; Prostanoid EP1 receptor
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human EP1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.
  • 基因功能参考文献：
    1. No significant differences in EP1 intensity were detected for histological, stage, grading, metastatic and recurrent subtypes in endometrial cancer. PMID: 29134301
    2. COX-2 expression appears to be linked to early hepatocellular carcinoma events (initiation), while EP1 receptor expression may participate in tumor progression and predict survival PMID: 27818595
    3. Copy number variation in PTGER1 is associated with NSAIDs-induced urticaria and/or angioedema PMID: 26959713
    4. suppression of EP1 prevented RAMA-induced FasL suppression in CLT85 cells at both the mRNA and protein levels PMID: 26211005
    5. A transient interaction between COX-2 and EP1 constitutes a feedback loop whereby an increase in COX-2 expression elevates EP1. PMID: 24614038
    6. NF-kappaB inhibitor suppressed 17-PT-PGE2-mediated FoxC2 upregulation. Immunohistochemistry showed p65, FoxC2, EP1 receptor and beta1-integrin were all highly expressed in the HCC cases PMID: 25289898
    7. COX-1, H446K' is significantly more sensitive to downregulation by EP . Together these data suggest that distinctive ubiquitination of COX-1 and COX-2 may be responsible for their different sensitivity to EP -mediated degradation. PMID: 24333447
    8. through complex formation with D1, EP1 signaling directs the D1 receptor through G(betagamma) to be coupled to AC7. PMID: 23842570
    9. PGE2-enhanced MMP2 expression is mediated through EP1 receptors and calcium signaling pathway-induced CREB phosphorylation in human cholangiocarcinoma cells. PMID: 23494562
    10. Our study suggests that the PGE EP1 receptor regulates FAK phosphorylation by activating the PKC/c-Src and EGFR signal pathways, which may coordinately regulate adhesion and migration in HCC PMID: 23525457
    11. PGE(2) -mediated NF-kappaB activation by simultaneous stimulation of EP(1) and EP(4) receptors induces maximal IL-8 promoter activation and IL-8 mRNA and protein induction PMID: 22924768
    12. Suggest that the anti-carcinogenic effects of EGCG in hepatocellular carcinoma might be mediated, at least partially, through the suppressing EP(1) receptor expression and PGE(2) production. PMID: 22555372
    13. new role for the EP(1) receptor in resolving inflammation through down-regulation of COX-2. PMID: 22474323
    14. Neuroblastoma express all four forms of PGE(2) receptors. PMID: 22276108
    15. A novel dendritic cell(DC) progenitor regulatory pathway in which PGE(2) signaling through EP1/EP3 receptors regulates Flt3 expression and downstream STAT3 activation and survivin expression, required for optimal progenitor survival and differentiation. PMID: 22110249
    16. The roles of prostaglandin EP 1 and 3 receptors in the control of human myometrial contractility. PMID: 22162473
    17. Data indicate that not only Cox-2 but also EP1 and EP3 could be important targets for chemosensitization and inhibition of metastasis in breast cancers that are resistant to chemotherapy. PMID: 21813027
    18. EP1 functions as a suppressor of tumor metastasis; loss of nuclear EP1 is associated with poorer overall survival and may contribute to disparities in outcome in different populations. PMID: 20858737
    19. We could not find an association of EP1 gene with suicide in the Japanese population PMID: 21447366
    20. the PGE(2) and EP1 interaction enhanced migration of oral cancer cells through an increase in ICAM-1 production PMID: 20647315
    21. Prostaglandin E2 enhances the migration of chondrosarcoma cells by increasing alpha2beta1 integrin expression through the EP1/PLC/PKCalpha/c-Src/NF-kappaB signal transduction pathway. PMID: 20178602
    22. The EP1 subtype of prostaglandin E2 receptor has a role in keratinocyte differentiation and expression in non-melanoma skin cancer. PMID: 19625175
    23. Agonists of EP(1) and EP(2) significantly increased aromatase activity levels, which were decreased by the corresponding antagonists. Generally reflective of changes in aromatase protein expression and the pattern of mRNA expression. PMID: 12788892
    24. the combined effects of EP(1) and EP(4) antagonists on spontaneous polyp formation in APC knockout mice PMID: 12841871
    25. Human corpus cavernosum and cultured smooth muscle cells express EP1, EP2 and EP3 receptors. PMID: 14562138
    26. COX-2 up-regulates VEGF-C and promotes lymphangiogenesis in human lung adenocarcinoma via the EP(1)/Src/HER-2/Neu signaling pathway. PMID: 14744769
    27. PGE2 stimulates extravillous trophoblast migration by signaling through EP1 receptors, increasing [Ca2+]i, and activating calpain PMID: 15886234
    28. EP1 receptor level increase in sensory neurones, and macrophage infiltration, appears to precede increased Cox-2 expression by macrophages in nerve injury PMID: 16393343
    29. EP(1) does not appear to have a significant direct effect on airway tone but acts as a modulator of the beta(2)AR, altering G(alphas) coupling via steric interactions imposed by the EP(1):beta(2)AR heterodimeric signaling complex PMID: 16670773
    30. participates in placentation through EVT invasion by up-regulating PGE2 production and PGE2 receptor expression in first trimester extravillous trophoblasts PMID: 17525067
    31. Results show co-expression of cyclooxygenase-2 and prostaglandin E2 receptors EP1, 2 and 4 in non-small cell lung cancer cells concomitant with the synthesis of PGE2. PMID: 17611676
    32. Expression of EP1 is frequently seen in human breast cancers. Nuclear expression of EP1 correlates with good prognosis markers like node negative status and progesterone receptor expression. PMID: 17906615
    33. Of the 4 EP receptor subtypes, smooth muscle cells in the human pulmonary vein express the EP4 and EP1 receptor subtypes PMID: 18516068
    34. Functional analysis of the mouse counterpart. PMID: 1160156

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart.
  • 数据库链接：

    HGNC: 9593

    OMIM: 176802

    KEGG: hsa:5731

    STRING: 9606.ENSP00000292513

    UniGene: Hs.159360