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  4. PPP1R16B Antibody

PPP1R16B Antibody

  • 货号：
    CSB-PA008661
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q96T49
  • 基因名：
    PPP1R16B
  • 别名：
    ANKRD4 antibody; Ankyrin repeat domain containing protein 4 antibody; ankyrin repeat domain protein 4 antibody; Ankyrin repeat domain-containing protein 4 antibody; CAAX box protein TIMAP antibody; hTIMAP antibody; KIAA0823 antibody; PP16B_HUMAN antibody; PPP1R16B antibody; Protein phosphatase 1 regulatory inhibitor subunit 16B antibody; protein phosphatase 1, regulatory (inhibitor) subunit 16B antibody; TGF beta inhibited membrane associated protein antibody; TGF-beta-inhibited membrane-associated protein antibody; TIMAP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human TIMAP.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation. Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity. Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the dephosphorylation of EEF1A1.
  • 基因功能参考文献：
    1. TIMAP is the versatile protein phosphatase 1 regulator in endothelial cells. (Review) PMID: 29140585
    2. NF2 localizes in nucleus when Ser518 is not phosphorylated, while phosphorylated form is present in cytoplasm and plasma membrane. Data suggest that binding of NF2 to TIMAP and EBP50 is critical in nuclear localization of NF2. (NF2 = neurofibromin 2; TIMAP = TGF-beta-inhibited membrane-associated protein; EBP50 = Ezrin-Radixin-Mosein binding phosphoprotein 50) PMID: 27871951
    3. phosphorylation of TIMAP on Ser331 by PKC represents a new mechanism of endothelial barrier regulation, through the inhibition of phospho-ERM dephosphorylation PMID: 27939168
    4. Results indicate that PKC-phosphorylated ECE-1 is a TIMAP-PP1c substrate and this phosphatase complex has an important role in endothelin-1 production of EC through the regulation of ECE-1 activity. PMID: 26806547
    5. ROCK phosphorylated eEF1A1 is a novel substrate for TIMAP-PP1 underlining the complex regulatory role of TIMAP in the endothelium. PMID: 26497934
    6. TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt inhibition in human glomerular endothelial cells. PMID: 25007873
    7. These data confirmed the barrier-protective role of TIMAP PMID: 21907835
    8. Data suggest that double-thiophosphorylation of TIMAP has minor effect on its binding ability to PP1c, but considerably attenuates its inhibitory effect on the activity of PP1c. PMID: 21466834
    9. TIMAP, a novel CAAX box protein regulated by TGF-beta1 and expressed in endothelial cells. PMID: 12055102
    10. involvement of TIMAP in PKA-mediated moesin dephosphorylation and the importance of this dephosphorylation in TIMAP-mediated endothelial cell barrier protection PMID: 18586956

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  • 亚细胞定位：
    Cell membrane. Cell membrane; Lipid-anchor. Nucleus. Cell projection.
  • 数据库链接：

    HGNC: 15850

    OMIM: 613275

    KEGG: hsa:26051

    STRING: 9606.ENSP00000299824

    UniGene: Hs.45719