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POLR1C Antibody

  • 货号：
    CSB-PA018324LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: HEK293 whole cell lysate, K562 whole cell lysate, NIH/3T3 whole cell lysate, HepG2 whole cell lysate, RAW264.7 whole cell lysate, Mouse liver tissue, Mouse kidney tissue, Rat heart tissue
      All lanes: POLR1C antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 40, 39 kDa
      Observed band size: 40 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) POLR1C Polyclonal antibody
  • Uniprot No.：
    O15160
  • 基因名：
    POLR1C
  • 别名：
    40kDa antibody; AA409007 antibody; AA959927 antibody; Ac2-127 antibody; AC40 antibody; AL024089 antibody; DNA directed RNA polymerase I subunit C antibody; DNA directed RNA polymerases I and III 40 kDa polypeptide antibody; DNA directed RNA polymerases I and III subunit RPAC1 antibody; DNA-directed RNA polymerase I subunit C antibody; DNA-directed RNA polymerases I and III 40 kDa polypeptide antibody; DNA-directed RNA polymerases I and III subunit RPAC1 antibody; MGC105583 antibody; MGC161175 antibody; POLR1C antibody; POLR1E antibody; Polymerase (RNA) I polypeptide C, 30kDa antibody; RNA polymerase 1 1 antibody; RNA polymerase I subunit C antibody; RNA polymerases I and III subunit AC1 antibody; RP3-337H4.4 antibody; RPA39 antibody; RPA40 antibody; RPA5 antibody; RPAC1 antibody; RPAC1_HUMAN antibody; RPC40 antibody; Rpo1 1 antibody; TCS3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human DNA-directed RNA polymerases I and III subunit RPAC1 protein (125-230AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，POLR1C Antibody (CSB-PA018324LA01HU)，的标记方式是Non-conjugated。对于POLR1C Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA018324LB01HU POLR1C Antibody, HRP conjugated ELISA
    FITC CSB-PA018324LC01HU POLR1C Antibody, FITC conjugated
    Biotin CSB-PA018324LD01HU POLR1C Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft.
  • 基因功能参考文献：
    1. Treacher Collins syndrome 3-associated mutation leads to the localization of POLR1C into the lysosome and inhibits chondrogenic differentiation, possibly explaining a portion of the pathological molecular basis underlying Treacher Collins syndrome. PMID: 29567474
    2. This study is the first to show that distinct mutations in a gene coding for a shared subunit of two RNA polymerases lead to selective modification of the enzymes' availability leading to two different clinical conditions. PMID: 26151409
    3. Mutations in TCOF1, POLR1C and POLR1D have all been implicated in causing TCS PMID: 24690222
    4. mutations in both alleles of POLR1C in three individuals with Treacher Collins syndrome. PMID: 21131976
    5. analyzed the kinetics of assembly and elongation of the RNA polymerase I complex on endogenous ribosomal genes in the nuclei of living cells with the use of in vivo microscopy PMID: 12446911

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  • 相关疾病：
    Treacher Collins syndrome 3 (TCS3); Leukodystrophy, hypomyelinating, 11 (HLD11)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family
  • 数据库链接：

    HGNC: 20194

    OMIM: 248390

    KEGG: hsa:9533

    STRING: 9606.ENSP00000361465

    UniGene: Hs.743509