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PLSCR4 Antibody

  • 货号：
    CSB-PA018210GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NRQ2
  • 基因名：
    PLSCR4
  • 别名：
    AV245873 antibody; Ca(2+)-dependent phospholipid scramblase 4 antibody; Cell growth inhibiting protein 43 antibody; Cell growth-inhibiting gene 43 protein antibody; GIG43 antibody; Phospholipid scramblase 4 antibody; PL scramblase 4 antibody; Pls4 antibody; PLS4_HUMAN antibody; Plscr4 antibody; TRA1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PLSCR4
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
  • 基因功能参考文献：
    1. the first report on the transcriptional regulation of hPLSCR4, where Snail was shown to downregulate the expression of Human phospholipid scramblase 4 PMID: 27363667
    2. biochemical and functional characterization of human phospholipid scramblase 4 PMID: 23089641
    3. Crystallographic analysis of mammalian importin alpha1 in complex with the hPLSCR4-NLS reveals this minimal NLS binds specifically and exclusively to the minor binding site of importin alpha PMID: 21690087
    4. SLPI is a ligand for PLSCR1 and PLSCR4, which also interact directly with the CD4 receptor at the cell surface of T lymphocytes PMID: 19333378
  • 亚细胞定位：
    Membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Phospholipid scramblase family
  • 组织特异性：
    Expressed in heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, uterus, small intestine and colon. Not detected in peripheral blood lymphocytes.
  • 数据库链接：

    HGNC: 16497

    OMIM: 607612

    KEGG: hsa:57088

    STRING: 9606.ENSP00000347038

    UniGene: Hs.477869