PLSCR1 Antibody

1. Inhibition of PLSCR1 decreased the antiviral activity of IFN against HBV. PMID: 30004207
2. Data suggest that PLSCR1 is involved in viral entry; here, herpes simplex viruses activate PLSCR1 and up-regulate flipping of phosphatidylserines and AKT to outside of plasma membrane shortly following HSV-1 or HSV-2 exposure. (PLSCR1 = phospholipid scramblase 1; AKT = proto-oncogene c-Akt) PMID: 29293671
3. wogonoside promotes the expression of PLSCR1 and enhances its nuclear translocation and binding to the 1, 4, 5-trisphosphate receptor 1 (IP3R1) promoter in AML patient-derived primary cells. Wogonoside activates IP3R1, in turn, promotes release of Ca(2+) from endoplasmic reticulum, and eventually leads to cell differentiation. PMID: 28492556
4. Data indicate heterogeneous expression of phospholipid scramblase 1 (PLSCR1) and suggest its possible implication in the response to anticancer therapies, especially to drugs promoting protective autophagy. PMID: 27248824
5. investigate how the polar aspartate residue is accommodated in lipid bilayers containing POPC with and without cholesterol, using all-atom molecular dynamics simulations PMID: 28372945
6. Human phospholipid scramblase 1 has five histidine residues and point mutations of histidine residues to alanine in hPLSCR1 resulted in 60 % loss in nuclease activity. PMID: 27206388
7. The mechanisms of pH-induced functional activation of hPLSCR1 are described. PMID: 26204401
8. PLSCR1 positively regulates hepatic carcinoma cell proliferation and migration through interacting with midkine PMID: 26642712
9. Suggest role for PLSCR1 in negatively regulating trophoblast fusion rather than directly promoting fusion. PMID: 25362260
10. PLSCR1 mediates the antiviral activity and anticarcinogenesis against hepatitis B virus by regulating HBx stability. PMID: 25365352
11. affinity of SCR for cholesterol-rich domains in membranes PMID: 25229146
12. This is the first biochemical evidence to prove the above hypothesis that hPLSCR1 is activated in heavy metal poisoning, which leads to bidirectional transbilayer movement of phospholipids. PMID: 23659204
13. The C-terminal transmembrane domain of human phospholipid scramblase 1 is essential for the protein flip-flop activity and Ca(2)-binding. PMID: 24343571
14. This is the first report showing the transcriptional regulation of hPLSCR1 expression by Snail TF and its possible implications in cancer progression. PMID: 24878522
15. PLSCR1 interacted with ANG in the cell nucleus and regulated rRNA transcription. PMID: 24356419
16. hPLSCR1 and PRD-hPLSCR2 showed Ca(2+)-dependent aggregation and scrambling activity PMID: 24648509
17. The data are in agreement with the possibility that PLSCR1 is an integral membrane protein. PMID: 24099740
18. Phospholipid Scramblase 1, an interferon-regulated gene located at 3q23, is regulated by SnoN/SkiL in ovarian cancer cells. PMID: 23621864
19. The C-terminal helix of human PLSCR1 is required for membrane insertion and calcium binding. PMID: 23590222
20. Phospholipid scramblase 1 expression is enhanced in patients with antiphospholipid syndrome. PMID: 22526829
21. Overexpression of PLSCR1 efficiently represses the Tat-dependent transactivation of the HIV-1 long terminal repeat (LTR) and reduces the nuclear translocation of Tat. PMID: 23501106
22. Calcium-dependent PLSCR-1 activity is required for compensatory endocytosis (but not for exocytosis) in neuroendocrine cells. PMID: 23426682
23. PLSCR1 is overexpressed in colorectal cancer and metastatic liver cancer. Silencing of PLSCR1 by siRNA inhibits the proliferation, adhesion, migration and invasion of tumor cells. PMID: 22893466
24. PLSCR1 may play an important role in the IFN-mediated repression of Tax-dependent transactivation during HTLV-1 infection. PMID: 22789739
25. this report identifies PLSCR1 as a protein that physically interacts with Receptor expressed in lymphoid tissues family members and is a potential substrate for phosphorylation by the OSR1 kinase in a RELT-dependent fashion. PMID: 22052202
26. PLSCR1 inhibited HBV replication through a reduction in the synthesis of viral proteins and DNA replication. PMID: 22342889
27. IFNalpha-induced PLSCR1 associates with the cytoskeleton after exposure to alpha-toxin, and cellular depletion of PLSCR1 negates IFN-induced protection from alpha-toxin. PMID: 22264514
28. summarizes the mechanisms and roles of PS exposure following platelet activation and discusses the recent identification of TMEM16F and its significance in the scrambling process PMID: 21958383
29. PLSCR1 might be used as a noninvasive serological diagnostic and prognostic biomarker for CRC. PMID: 20927484
30. PLSCR1 was required for the initial attachment of HCV onto hepatoma cells, where it specifically interacted with entry factor OCLN. We show that PLSCR1 is a novel attachment factor for HCV entry. PMID: 21806988
31. Interferon tau induces expression of DDX58 and PLSCR1 via the classical STAT1-mediated cell signaling pathway. PMID: 20926691
32. PLSCR1 interacts with the tandem repeat region of ECM1a in the dermal epidermal junction zone of human skin. PMID: 20870722
33. Monocytes in systemic lupus erythematosus patients had enhanced PLSCR1 mRNA expression, as well as increased fibrin turnover and cell-surface PS exposure. PMID: 20516018
34. Suppression of ovarian carcinoma cell growth in vivo by the interferon-inducible plasma membrane protein, phospholipid scramblase 1. PMID: 11809687
35. PLSCR1 co-localizes with the epidermal growth factor (EGF) receptor in lipid rafts and plays a role in the EGF-induced metabolic or mitogenic response. PMID: 12009895
36. expression has a role in the induction of differentiation of human myeloid leukemia cells into granulocytes. PMID: 12031648
37. Trafficking of PLSCR1 to the plasma membrane is dependent upon palmitoylation of the polypeptide; in the absence of palmitoylation, PLSCR1 traffics into the nucleus. PMID: 12564925
38. Identification of domains for PLSCR1 and BACE binding and their colocalization in the Golgi area and endosomal compartments suggest involvement of PLSCR1 in the intracellular distribution and/or recruitment of BACE into the lipid raft. PMID: 12586838
39. phospholipid scramblase 1 plays a role in ischemic injury in the human hippocampus PMID: 12605885
40. PLSCR1, through its interaction with Shc, promotes Src kinase activation through the EGF receptor. PMID: 12871937
41. Higher MmTRA1b mRNA levels were associated with significantly longer overall survival in AML, especially in AML-M4 patients, independent of chromosomal aberrations PMID: 14654079
42. both PLSCR1 and phospholipid flip-flop characterize uropod raft domains of polarized neutrophils PMID: 14766753
43. Data support a mechanism of receptor-mediated nuclear import of PLSCR1 and suggest a potential nuclear function for this plasma membrane protein, mediated through potential interaction with genomic DNA. PMID: 15035622
44. as a protein induced upon PKCdelta activation, PLSCR1 is required for ATRA- and PMA-triggered leukemic cell differentiation PMID: 15308560
45. PLSCR1, which is itself an IFN-stimulated gene-encoded protein, provides a mechanism for amplifying and enhancing the IFN response through increased expression of a select subset of potent antiviral genes PMID: 15308695
46. x-ray crystallography shows that there is a nonclassical nuclear localization signal in PLSCR1 with a unique binding site in importin alpha PMID: 15611084
47. PLSCR1 binds to the promoter region of the IP3R1 gene to enhance its expression PMID: 16091359
48. protein kinase Cdelta and JNK have roles in Ifn-alpha induced expression of phospholipid scramblase 1 through STAT1 PMID: 16260419
49. PR3 externalization depended on PLSCR1 PMID: 17712045
50. the same region of the cytoplasmic domain of PLSCR1 is involved in the binding to CD4 and SLPI PMID: 19333378

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HGNC: 9092

OMIM: 604170

KEGG: hsa:5359

STRING: 9606.ENSP00000345494

UniGene: Hs.130759