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PLEKHF1 Antibody

  • 货号：
    CSB-PA018167GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q96S99
  • 基因名：
    PLEKHF1
  • 别名：
    PLEKHF1 antibody; APPD antibody; LAPF antibody; ZFYVE15 antibody; Pleckstrin homology domain-containing family F member 1 antibody; PH domain-containing family F member 1 antibody; Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains antibody; Apoptosis-inducing protein antibody; PH and FYVE domain-containing protein 1 antibody; Phafin-1 antibody; Zinc finger FYVE domain-containing protein 15 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PLEKHF1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8.
  • 基因功能参考文献：
    1. The results suggest that in addition to its role in endosome transport, phafin1 is also involved in lysosomal targeting and autophagosome formation. PMID: 22115783
    2. functional characterization of LAPF, a novel lysosome-associated apoptosis-inducing protein containing PH and FYVE domains; LAPF may launch caspase-independent apoptosis through the lysosomal-mitochondrial pathway PMID: 16188880
  • 亚细胞定位：
    Nucleus. Cytoplasm, perinuclear region. Lysosome. Note=Translocates to lysosome during apoptosis.
  • 组织特异性：
    Highly expressed in heart and skeletal muscle. Weakly expressed in brain, thymus, spleen, kidney, liver, small intestine, placenta and lung.
  • 数据库链接：

    HGNC: 20764

    OMIM: 615200

    KEGG: hsa:79156

    STRING: 9606.ENSP00000389787

    UniGene: Hs.466383