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PKD1L1 Antibody

  • 货号：
    CSB-PA823467LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA823467LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA823467LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PKD1L1 Polyclonal antibody
  • Uniprot No.：
    Q8TDX9
  • 基因名：
    PKD1L1
  • 别名：
    PKD1L1 antibody; UNQ5785/PRO19563 antibody; Polycystic kidney disease protein 1-like 1 antibody; PC1-like 1 protein antibody; Polycystin-1L1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Polycystic kidney disease protein 1-like 1 protein (921-1164AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PKD1L1 Antibody (CSB-PA823467LA01HU)，的标记方式是Non-conjugated。对于PKD1L1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA823467LB01HU PKD1L1 Antibody, HRP conjugated ELISA
    FITC CSB-PA823467LC01HU PKD1L1 Antibody, FITC conjugated
    Biotin CSB-PA823467LD01HU PKD1L1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. Does not constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning.
  • 基因功能参考文献：
    1. The s report that the human PKD2-L1 selectivity filter is partially selective to calcium ions (Ca(2+)) moving into the cell, but blocked by high internal Ca(2+)concentrations, a unique feature of this transient receptor potential (TRP) channel family member. PMID: 27348301
    2. identification of bi-allelic PKD1L1 mutations recapitulates previous findings regarding phenotypic consequences of loss of function of the orthologous genes in mice and medaka fish and further expands our understanding of genetic contributions to laterality defects in humans PMID: 27616478
  • 相关疾病：
    Heterotaxy, visceral, 8, autosomal (HTX8)
  • 亚细胞定位：
    Cell projection, cilium membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Polycystin family
  • 组织特异性：
    Detected in testis and in fetal and adult heart.
  • 数据库链接：

    HGNC: 18053

    OMIM: 609721

    KEGG: hsa:168507

    STRING: 9606.ENSP00000289672

    UniGene: Hs.195979