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PARP10 Antibody

  • 中文名称：
    PARP10兔多克隆抗体
  • 货号：
    CSB-PA992379
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA992379(PARP10 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA992379(PARP10 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q53GL7
  • 基因名：
    PARP10
  • 别名：
    PARP10 antibody; Protein mono-ADP-ribosyltransferase PARP10 antibody; EC 2.4.2.- antibody; ADP-ribosyltransferase diphtheria toxin-like 10 antibody; ARTD10 antibody; Poly [ADP-ribose] polymerase 10 antibody; PARP-10 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human PARP10
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity. Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA.
  • 基因功能参考文献：
    1. PARP10 expression decreased upon fasting, a condition that is characterized by increases in mitochondrial biogenesis. Finally, lower PARP10 expression is associated with increased fatty acid oxidation PMID: 29293500
    2. ARTD10 plays roles in immunity, metabolism ,apoptosis and DNA damage repair. [review] PMID: 24878761
    3. PARP10 binding to PCNA is required for translesion DNA synthesis. PMID: 24695737
    4. study results show that the interaction between PARP10 and NS1 of H5N1 avian influenza virus can change cell cycle, and PARP10 can affect virus replication PMID: 22176891
    5. novel PARP enzyme involved in the control of cell proliferation PMID: 15674325
    6. Overexpression of PARP10 results in loss of cell viability, although down-expression by short hairpin RNA leads to delayed G1 progression and concomitant cell death. PMID: 16455663
    7. alternative catalytic mechanism for PARP10 compared to PARP1 in which the acidic target residue of the substrate functionally substitutes for the catalytic glutamate by using substrate-assisted catalysis to transfer ADP-ribose PMID: 18851833

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  • 亚细胞定位：
    Nucleus, nucleolus. Cytoplasm.
  • 组织特异性：
    Highly expressed in spleen and thymus. Intermediate levels in liver, kidney, pancreas, prostate, testis, ovary, intestine, and leukocytes. Low expression in heart, brain, placenta, lung, skeletal muscle, and colon.
  • 数据库链接：

    HGNC: 25895

    OMIM: 609564

    KEGG: hsa:84875

    STRING: 9606.ENSP00000325618

    UniGene: Hs.348609