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PAK7 Antibody

  • 货号：
    CSB-PA265580
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from rat brain cells, using PAK7 antibody.
    • Immunohistochemistry analysis of paraffin-embedded human brain tissue, using PAK7 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PAK5 Polyclonal antibody
  • Uniprot No.：
    Q9P286
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from C-terminal of Human PAK7.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
  • 基因功能参考文献：
    1. PAK5 Induces EMT and Promotes Cell Migration and Invasion by Activating the PI3K/AKT Pathway in Ovarian Cancer. PMID: 30245957
    2. Mechanistic studies demonstrated that miR-106a-5p directly bound to the 3'-UTR of the PAK5 mRNA and mediated a decrease in the protein expression of PAK5. PMID: 29072688
    3. PAK5-mediated phosphorylation and nuclear translocation of NF-kappaB-p65 promotes breast cancer cell proliferation in vitro and in vivo PMID: 29041983
    4. p21-activated kinase (PAK7) was identified as the putative target of miR492 in osteosarcoma (OS), and we further found a significantly inverse correlation between PAK7 and miR492 in OS specimens. PMID: 28677719
    5. As PAK7 has been implicated in the progression of various tumor types, silencing the expression of PAK7 via pairing with miR526a may be an effective strategy in tumor suppression. PMID: 28560394
    6. These findings indicate that aberrant PAK7 expression is associated with the occurrence of metastasis and poor clinical outcomes of human colon cancer by promoting the epithelial to mesechymal transition PMID: 27323857
    7. Data suggest expression of ECAD (E-cadherin) in bladder cancer cell lines correlates with presence of intercellular junctions and level of PAK5 (p21-activated kinase PAK5 protein) expression; endogenous PAK5 is localized to intercellular junctions and interacts with ECAD; depletion of PAK5 expression reduces integrity of intercellular junctions; PAK5 mRNA levels are reduced in bladder cancer compared with normal controls. PMID: 28232500
    8. model suggests PAK5 self-association interferes with AID binding to the catalytic domain, thus maintaining its high activity. PMID: 27095851
    9. PAK7 expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
    10. PAK7 is overexpressed in human esophageal squamous cell cancer samples and correlated with lymph node metastasis. PMID: 26682509
    11. E47 is a novel substrate of PAK5, and PAK5-mediated phosphorylation of E47 promotes epithelial-mesenchymal transition and metastasis of colon cancer. PMID: 26212009
    12. Aurora-A induced PAK7 expression in esophageal cancer cells. PMID: 25436453
    13. results suggest that the inhibition of PAK5 by RNA interference might efficiently suppress tumor development of glioma cells with PAK5 high expression. PMID: 25632266
    14. miR-129 suppresses tumor cell growth and invasion by targeting PAK5 in hepatocellular carcinoma. PMID: 26116538
    15. PAK7 promotes cell proliferation and tumorigenesis PMID: 25052921
    16. It inhibits glioma cell migration and invasion potentially through the PAK5-Egr1-MMP2 signaling pathway. PMID: 24062079
    17. PAK5 functions as an oncogenic kinase in tumor cellular regulation PMID: 24869804
    18. Results demonstrate that PAK7 is developmentally co-expressed with another known psychosis risk gene (DISC1) suggesting a potential molecular mechanism involving aberrant synapse development and plasticity. PMID: 24474471
    19. PAK5 is correlated to human epithelial ovarian cancer (EOC) and increased PAK5 expression promotes EOC progression. PMID: 23877225
    20. The PAK5-Egr1-MMP2 signaling pathway is a critical regulator of cell migration and invasion in lung cancer cells. PMID: 23696025
    21. identified three kinases with gain-of-function mutations in lung cancer, namely FGFR4, MAP3K9, and PAK5. Mutations in these kinases are activating toward the ERK pathway, and targeted depletion of the mutated kinases inhibits proliferation PMID: 23836671
    22. PAK7 is a new hallmark of gastric cancer, PAK7 may contribute to gain of tumor growth potential, acting by affecting the expression of cell cycle regulators. PMID: 23106939
    23. Data show that both Pak5 and constitutively active Pak4, the founding member of the Group B Paks, directly phosphorylate p120 in vitro. PMID: 20564219
    24. PAK5 suppresses the activity of microtubule affinity-regulating kinase 2 (MARK2) toward its target, tau protein. PMID: 16014608
    25. Nucleocytoplasmic shuttling of PAK7 regulates its antiapoptotic properties. PMID: 16581795
    26. Study demonstrated that PAK5 expression increased significantly with malignant progression of CRC (colorectal cancer), and that PAK5 might promote CRC metastasis by regulating CRC cell adhesion and migration. PMID: 19415746

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  • 亚细胞定位：
    Mitochondrion. Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 组织特异性：
    Predominantly expressed in brain.
  • 数据库链接：

    HGNC: 15916

    OMIM: 608038

    KEGG: hsa:57144

    STRING: 9606.ENSP00000322957

    UniGene: Hs.32539