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OXCT1 Antibody

  • 货号：
    CSB-PA017306LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: OXCT1 antibody at 2µg/ml + Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/15000 dilution
      Predicted band size: 57, 14 kDa
      Observed band size: 57 kDa
    • Immunohistochemistry of paraffin-embedded human lymphoid tissue using CSB-PA017306LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) OXCT1 Polyclonal antibody
  • Uniprot No.：
    P55809
  • 基因名：
  • 别名：
    3 oxoacid CoA transferase 1 antibody; 3-oxoacid CoA-transferase 1 antibody; EC 2.8.3.5 antibody; OTTHUMP00000120012 antibody; OTTHUMP00000221550 antibody; OXCT antibody; Oxct1 antibody; SCOT antibody; Scot S antibody; Scot-S antibody; SCOT1_HUMAN antibody; Somatic type succinyl CoA:3 oxoacid CoA transferase antibody; Somatic-type succinyl-CoA:3-oxoacid CoA-transferase antibody; Succinyl CoA:3 ketoacid CoA transferase antibody; Succinyl CoA:3 ketoacid coenzyme A transferase 1 mitochondrial antibody; Succinyl CoA:3 oxoacid CoA transferase antibody; Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial protein (40-520AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，OXCT1 Antibody (CSB-PA017306LA01HU)，的标记方式是Non-conjugated。对于OXCT1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA017306LB01HU OXCT1 Antibody, HRP conjugated ELISA
    FITC CSB-PA017306LC01HU OXCT1 Antibody, FITC conjugated
    Biotin CSB-PA017306LD01HU OXCT1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
  • 基因功能参考文献：
    1. Crystal structure of human SCOT, providing a molecular understanding of the reported mutations based on their potential structural effects. PMID: 23420214
    2. Case Report: Succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency causes episodic ketoacidotic crises and no apparent symptoms between them. PMID: 20652411
    3. Data show that the ketone body metabolizing enzymes BDH1, BDH2, OXCT1 and ACAT1 were expressed at the mRNA and protein level in all glioma cell lines. PMID: 21791085
    4. Missense Mutations in succinyl-CoA:3-ketoacid CoA transferase is associated with Ketoacidosis. PMID: 21296660
    5. Results demonstrate that h-Scot-t is a single intronless gene specifically expressed in the testis. PMID: 11756565
    6. In SCOT-deficient patients retaining some residual activity, permanent ketosis may be absent. PMID: 15496607
    7. A 6-bp deletion at the splice donor site of intron 1 resulted in the absence of a full-length mature SCOT mRNA with faint amounts of aberrantly spliced transcripts using a cryptic splice donor site within exon 1. PMID: 16765626
    8. the R268H mutation is a ketoacidosis-causing one PMID: 17706444
    9. liver-specific silencing of the SCOT gene expression may be mediated in part by its 5'-flanking sequence PMID: 18648183
    10. The activities of pyruvate carboxylase (SCOT) were decreased by 65% in pancreatic islets of patients with type 2 diabetes. PMID: 19296078

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  • 相关疾病：
    Succinyl-CoA:3-oxoacid CoA transferase deficiency (SCOTD)
  • 亚细胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    3-oxoacid CoA-transferase family
  • 组织特异性：
    Abundant in heart, followed in order by kidney, brain, and muscle, whereas in liver it is undetectable; also detectable in leukocytes and fibroblasts.
  • 数据库链接：

    HGNC: 8527

    OMIM: 245050

    KEGG: hsa:5019

    STRING: 9606.ENSP00000196371

    UniGene: Hs.278277