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OSTF1 Antibody

  • 货号：
    CSB-PA017266GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q92882
  • 基因名：
    OSTF1
  • 别名：
    bA235O14.1 antibody; FLJ20559 antibody; OSF antibody; Osteoclast stimulating factor 1 antibody; Osteoclast-stimulating factor 1 antibody; Ostf1 antibody; OSTF1_HUMAN antibody; SH3P2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human OSTF1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.
  • 基因功能参考文献：
    1. Data show that SH3P2 was phosphorylated on Ser(202) by ribosomal S6 kinase (RSK) in an ERK pathway-dependent manner, and such phosphorylation inhibited the ability of SH3P2 to suppress cell motility. PMID: 21501342
    2. SH3P2, a novel component of adhesion sites, is involved in Cbl and Src-mediated pathways PMID: 15135048
    3. Crystals of human osteoclast-stimulating factor were obtained by the hanging-drop vapour-diffusion method using X ray crystallography. PMID: 16508112
    4. The SH3 domain structure of osteoclast stimulating factor at atomic resolution provides an accurate framework for structure-based design of its inhibitors. PMID: 16946461
    5. The peptide-binding groove of OSTF-SH3 domain adopts a conformation different from other SH3 domains and probably needs a conformational switch for binding to its proline-rich ligand; this status is possibly regulated by the C-terminal ankyrin repeats. PMID: 19137598

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  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Ubiquitously expressed. Present in osteoclasts (at protein level).
  • 数据库链接：

    HGNC: 8510

    OMIM: 610180

    KEGG: hsa:26578

    STRING: 9606.ENSP00000340836

    UniGene: Hs.494192