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OGFR Antibody

  • 货号：
    CSB-PA246366
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from HeLa cells and HepG2 cells, using OGFR antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) OGFR Polyclonal antibody
  • Uniprot No.：
    Q9NZT2
  • 基因名：
    OGFR
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human OGFR.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation.
  • 基因功能参考文献：
    1. Morphine interacts with OGFR and may suppress lung cancer proliferation and progression. PMID: 27167686
    2. The blockade of OGF signaling by MNTX releases cells from their arrest and boosts the effect of Doc PMID: 25853862
    3. The OGF-OGFr axis may be a feasible target for treatment of cancer of the ovary (i) in a prophylactic fashion, (ii) following cytoreduction or (iii) in conjunction with standard chemotherapy for additive effectiveness PMID: 23856908
    4. OGF-OGFr axis is a determinant of the progression of human ovarian cancer PMID: 22328595
    5. These data are the first to report that theOGFr system is a native biological regulator of cell proliferation in Hepatocellular carcinoma PMID: 19923357
    6. OGF and OGFR are present in follicular-derived thyroid cancers, and that OGF serves in a inhibitory manner to maintain homeostasis of cell proliferation. PMID: 19835629
    7. Gene therapy to reinstate more OGFr and enhance OGFr function, could serve as a useful treatment for inhibiting tumor progression in head and neck cancers. PMID: 16685459
    8. Opioid growth factor receptor is unaltered with the progression of human pancreatic and colon cancers PMID: 16820893
    9. These data indicate that the OGF receptor is integral to cell replication of SCCHN, and support treatment modalities that amplify OGFr in order to decrease the growth of these neoplasias. PMID: 17273790
    10. supports opioid growth factor receptor (OGFr) gene function as a regulator of cell proliferation that impacts on tumorigenic expression, and suggest that molecular and pharmacological manipulation of OGFr may prevent or delay human pancreatic cancer. PMID: 18636152
    11. Results indicate that both p16(INK4a) and p21(WAF1/CIP1) are required for the opioid growth factor (OGF)-OGF receptor axis to inhibit cell proliferation in normal cells. PMID: 18923142
    12. the regulation of cell proliferation by the OGF-OGFr axis is dependent on nucleocytoplasmic translocation and reliant on the integrity of two NLSs in OGFr to interact with transport receptors. PMID: 19244545
    13. Cell proliferation of human ovarian cancer is regulated by the opioid growth factor-opioid growth factor receptor axis. PMID: 19297547
    14. Opioid growth factor-opioid growth factor receptor axis is a physiological determinant of cell proliferation in diverse human cancers. PMID: 19675283

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=The OGF/OGFR complex is probably translocated to the nucleus.
  • 蛋白家族：
    Opioid growth factor receptor family
  • 组织特异性：
    Highly expressed in the heart and liver, moderately in skeletal muscle and kidney and to a lesser extent in brain and pancreas. Expressed in fetal tissues including liver and kidney.
  • 数据库链接：

    HGNC: 15768

    OMIM: 606459

    KEGG: hsa:11054

    STRING: 9606.ENSP00000290291

    UniGene: Hs.67896