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NKD2 Antibody

  • 货号：
    CSB-PA015831GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q969F2
  • 基因名：
  • 别名：
    hNkd2 antibody; Naked 2 antibody; Naked-2 antibody; nkd2 antibody; NKD2_HUMAN antibody; Protein naked cuticle homolog 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human NKD2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.
  • 基因功能参考文献：
    1. ZFAS1 over-expression confers an oncogenic function in gastric cancer and this function is partly dependent on repressing KLF2 and NKD2 PMID: 27246976
    2. NKD2 is frequently methylated in human esophageal cancer, and the expression of NKD2 is regulated by promoter region methylation. NKD2 suppresses esophageal cancer progression by inhibiting Wnt signaling both in vitro and in vivo. PMID: 27374455
    3. NKD2 is the key molecular marker to study the progression of osteosarcoma development, and it may be used for better prognosis of the disease in early stage PMID: 27424978
    4. curcumin significantly inhibited the proliferation of colorectal cancer cells and upregulated the expression of NKD2 in SW620 colorectal cancer cells. PMID: 26985708
    5. NKD2 regulates osteosarcoma cell proliferation and apoptosis by inhibiting the Wnt signaling.MiR-130b targets NKD2 and regulates the Wnt signaling to promote proliferation and inhibit apoptosis of osteosarcoma cells. PMID: 26902120
    6. NKD2 is frequently methylated in human breast cancer, and the expression of NKD2 is regulated by promoter region methylation. PMID: 26124080
    7. NKD2 methylation is associated with cell differentiation, TNM stage and distant metastasis significantly (all P < 0.05), and the overall survival time is longer in NKD2 unmethylated group compared to NKD2 methylated group (P < 0.05). PMID: 26396173
    8. NKD2 antagonizes Wnt signaling: myristoylated NKD2 interacts with Dvl-1 at the plasma membrane, and this interaction leads to their mutual ubiquitin-mediated proteasomal degradation. PMID: 20177058
    9. NKD2 represents a candidate target of 5p amplifications in soft tissue sarcomas and might play a crucial role during the progression of this disease. PMID: 16752383
    10. Naked2 acts as a cargo recognition and targeting (CaRT) protein to ensure proper delivery, tethering, and fusion of TGF-alpha-containing vesicles to a distinct region at the basolateral surface of polarized epithelial cells. PMID: 17553928
    11. identify an EGFR-independent action of TGF-alpha, in which it protects Naked2 from proteasomal degradation, thus ensuring its delivery to the basolateral surface of polarized epithelial cells PMID: 18757723

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  • 亚细胞定位：
    Cell membrane. Cytoplasm. Cytoplasmic vesicle.
  • 蛋白家族：
    NKD family
  • 组织特异性：
    Expressed in kidney, lung, pancreas and spleen.
  • 数据库链接：

    HGNC: 17046

    OMIM: 607852

    KEGG: hsa:85409

    STRING: 9606.ENSP00000296849

    UniGene: Hs.240951