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NAA25 Antibody

  • 货号：
    CSB-PA617948ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: NAA25 antibody at 2.12µg/ml
      Lane 1: Mouse liver tissue
      Lane 2: Mouse kidney tissue
      Lane 3: Hela whole cell lysate
      Lane 4: 293T whole cell lysate
      Lane 5: A549 whole cell lysate
      Lane 6: HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 113, 100 kDa
      Observed band size: 113, 100 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA617948ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA617948ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NAA25 Polyclonal antibody
  • Uniprot No.：
    Q14CX7
  • 基因名：
    NAA25
  • 别名：
    C12orf30 antibody; DKFZp667K2112 antibody; FLJ1308 antibody; MDM20 antibody; Mitochondrial distribution and morphology 20 antibody; Mitochondrial distribution and morphology protein 20 antibody; N(alpha)-acetyltransferase 25, NatB auxiliary subunit antibody; N-alpha-acetyltransferase 25, NatB auxiliary subunit antibody; N-terminal acetyltransferase B complex subunit MDM20 antibody; N-terminal acetyltransferase B complex subunit NAA25 antibody; Naa25 antibody; NAA25_HUMAN antibody; NAP1 antibody; NatB complex subunit MDM20 antibody; p120 antibody; TPR repeat-containing protein C12orf30 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human N-alpha-acetyltransferase 25, NatB auxiliary subunit protein (703-972AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression.
  • 基因功能参考文献：
    1. Mdm20 acts as a novel regulator of Rictor, thereby controlling mTORC2 activity, and leading to the activation of PKCalphaS657 and FoxO1. PMID: 26600389
    2. The human NatB complex composed of Naa20 (NAT3) and Naa25 (MDM20) N-terminally acetylates Met-Glu-, Met-Asp-, Met-Asn- and Met-Gln- N-termini, and is important for the structure and function of actomyosin fibers and for proper cellular migration. PMID: 22814378
    3. The C120rf30 gene maps into a region of extensive linkage disequilibrium including several genes that represent functional candidates of type 1 diabetes-susceptibility. PMID: 20089178
    4. Human N-acetyltransferase complexe NatB consists of human N-acetyltransferase 3 and human MDM20. The hMDM20 knockdown decreased the fraction of cells in G(0)/G(1)-phase and increased the fraction of cells in the sub-G(0)/G(1)-phase. PMID: 18570629
    5. There are associations between juvenile idiopathic arthritis and variants in the TNFAIP3, STAT4, and C12orf30 regions that have previously shown associations with other autoimmune diseases, including rheumatoid arthritis and systemic lupus erythematosus. PMID: 19565500
    6. hMdm20 (C12orf30) is an auxiliary subunit of the human NatB N-terminal acetyltransferase complex while hNat3 (NAT5) is the catalytic subunit. This ribosome associated complex acetylates nascent Met-Asp/Glu- polypeptides. PMID: 18570629

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    MDM20/NAA25 family
  • 数据库链接：

    HGNC: 25783

    OMIM: 612755

    KEGG: hsa:80018

    STRING: 9606.ENSP00000261745

    UniGene: Hs.530941