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NAA15 Antibody

  • 中文名称：
    NAA15兔多克隆抗体
  • 货号：
    CSB-PA863143LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Rat brain tissue, Rat kidney tissue, Mouse heart tissue, Mouse liver tissue
      All lanes: NAA15 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 102, 62 kDa
      Observed band size: 95 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NAA15 Polyclonal antibody
  • Uniprot No.：
    Q9BXJ9
  • 基因名：
    NAA15
  • 别名：
    5730450D16Rik antibody; 6330400I15 antibody; ASTBDN antibody; GA19 antibody; Gastric cancer antigen Ga19 antibody; MGC29428 antibody; mNAT1 antibody; N alpha acetyltransferase 15, NatA auxiliary subunit antibody; N terminal acetyltransferase antibody; N(alpha) acetyltransferase 15, NatA auxiliary subunit antibody; N-alpha-acetyltransferase 15 antibody; N-terminal acetyltransferase antibody; Naa15 antibody; NAA15_HUMAN antibody; NatA auxiliary subunit antibody; NATH antibody; NMDA receptor regulated 1 antibody; NMDA receptor regulated protein 1 antibody; NMDA receptor-regulated protein 1 antibody; Protein tubedown 1 antibody; Protein tubedown-1 antibody; Tbdn 1 antibody; Tbdn100 antibody; Transcriptional coactivator tubedown 100 antibody; tubedown-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat, Mouse
  • 免疫原：
    Recombinant Human N-alpha-acetyltransferase 15, NatA auxiliary subunit protein (742-865AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NAA15 Antibody (CSB-PA863143LA01HU)，的标记方式是Non-conjugated。对于NAA15 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA863143LB01HU NAA15 Antibody, HRP conjugated ELISA
    FITC CSB-PA863143LC01HU NAA15 Antibody, FITC conjugated
    Biotin CSB-PA863143LD01HU NAA15 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Auxillary subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase (NAT) activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.
  • 基因功能参考文献：
    1. individuals with copy-number variant (CNV) deletions involving NAA15 and surrounding genes can present with mild intellectual disability, mild dysmorphic features, motor delays, and decreased growth. PMID: 29656860
    2. In combination with acetylation assays, the HypK N-terminal region is identified as a negative regulator of the NatA acetylation activity PMID: 28585574
    3. s highlight NAA15 as a novel candidate ID gene based on the vital role of NAA15 in the generation and differentiation of neurons in neonatal brain. PMID: 28990276
    4. Human Naa15 (NATH) and Naa10 (ARD1) form a stable NatA complex which associates with ribosomes and performs co-translational N-terminal acetylation; Naa15 (NATH) and Naa10 (ARD1) are cleaved during apoptosis resulting in decreased acetyltransferase activity PMID: 15496142
    5. Development of the first N-terminal acetyltransferase (NAT) inhibitors, including inhibitors to the NatA complex composed of Naa10 (ARD1) and Naa15 (NATH). PMID: 23557624
    6. Protein N-terminal acetyltransferases (NATs), including the NatA complex composed of Naa10 (ARD1) and Naa15 (NATH), act as N-terminal propionyltransferases. PMID: 23043182
    7. Data indicate that the physical interaction between HYPK and NatA Naa10/15 seems to be of functional importance both for huntingtin aggregation and for N-terminal acetylation. PMID: 20154145
    8. NATH, a novel gene overexpressed in papillary thyroid carcinomas. PMID: 12140756
    9. description of the human homologue of Nat1p, NATH (NAT human), as the binding partner of the hARD1 (human ARD1) protein PMID: 15496142
    10. levels of endogenous NATH and hARD1 proteins in thyroid papillary carcinoma patients; results suggest that NATH positively affects the level of hARD1 protein both in vivo and in cell cultures PMID: 16279846
    11. Loss of retinal endothelial Tbdn-1 expression may be a contributing factor in retinal blood vessel proliferation in retinopathy of prematurity. PMID: 16518308
    12. Essential role in cell survival through protein N-alpha-acetylation. PMID: 16518407
    13. NATH complexes with hARD1 in a ribosomal associated protein-N-acetyltransferase complex. PMID: 15496142

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes.
  • 组织特异性：
    Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, u
  • 数据库链接：

    HGNC: 30782

    OMIM: 608000

    KEGG: hsa:80155

    STRING: 9606.ENSP00000296543

    UniGene: Hs.745047