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Mybpc3 Antibody

  • 货号：
    CSB-PA015267YA01RA
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Rattus norvegicus (Rat) Mybpc3 Polyclonal antibody
  • Uniprot No.：
    P56741
  • 基因名：
    Mybpc3
  • 别名：
    Mybpc3 antibody; Myosin-binding protein C antibody; cardiac-type antibody; Cardiac MyBP-C antibody; C-protein antibody; cardiac muscle isoform antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Rat
  • 免疫原：
    Recombinant Rat Myosin-binding protein C, cardiac-type protein (645-864AA)
  • 免疫原种属：
    Rattus norvegicus (Rat)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Mybpc3 Antibody (CSB-PA015267YA01RA)，的标记方式是Non-conjugated。对于Mybpc3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA015267YB01RA Mybpc3 Antibody, HRP conjugated ELISA
    FITC CSB-PA015267YC01RA Mybpc3 Antibody, FITC conjugated
    Biotin CSB-PA015267YD01RA Mybpc3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
  • 基因功能参考文献：
    1. Data show that expression of mutant protein cMyBP-C (cMyBP-C(C10mut)) in cultured adult rat cardiomyocytes led to improper localization and contractile dysfunction. PMID: 25583989
    2. These results show that the N-terminal region of MyBP-C stabilizes the ON state of thin filaments and the OFF state of thick filaments and lead to a novel hypothesis for the physiological role of MyBP-C in the regulation of cardiac contractility. PMID: 25512492
    3. Expression of an actin binding-deficient cMyBP-C resulted in abnormal cytosolic distribution of the protein, indicating that interaction with actin is essential for the formation and/or maintenance of normal cMyBP-C sarcomeric distribution. PMID: 22982234
    4. N' region of cMyBP-C is toxic to cardiomyocytes and able to induce cell death. PMID: 22527638
    5. this study suggests that cMyBP-C is an easily releasable myofilament protein that is dephosphorylated, degraded and released into the circulation post-MI. PMID: 21971072

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  • 蛋白家族：
    Immunoglobulin superfamily, MyBP family
  • 数据库链接：

    KEGG: rno:295929

    STRING: 10116.ENSRNOP00000016652

    UniGene: Rn.162668