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MORF4L1 Antibody

  • 货号：
    CSB-PA006746
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of mouse cells using MRG15 Polyclonal Antibody
    • Western blot analysis of Mouse-kidney mouse-brain lysis using MRG15 antibody.
  • 其他：

产品详情

  • Uniprot No.：
    Q9UBU8
  • 基因名：
    MORF4L1
  • 别名：
    CG6363 antibody; Eaf3 antibody; Esa1p associated factor 3 homolog antibody; FWP006 antibody; HsT17725 antibody; MEAF3 antibody; MO4L1_HUMAN antibody; MORF related gene on chromosome 15 antibody; MORF-related gene 15 protein antibody; Morf4l1 antibody; MORFRG15 antibody; Mortality factor 4 like 1 antibody; Mortality factor 4 like protein 1 antibody; Mortality factor 4-like protein 1 antibody; MRG15 antibody; Protein MSL3-1 antibody; S863-6 antibody; Transcription factor-like protein MRG15 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human MRG15.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.
  • 基因功能参考文献：
    1. PALB2 associates with active genes through its major binding partner, MRG15, which recognizes histone H3 trimethylated at lysine 36 (H3K36me3) by the SETD2 methyltransferase PMID: 28673974
    2. Both MRG15 CD and Pf1 PHD1 bind to their targets with >100 muM affinity. PMID: 22728643
    3. While the present study expands on the role of MRG15 in the control of genomic stability, weak associations can not be ruled out for potential low-penetrance variants at MORF4L1 and breast cancer risk among BRCA2 mutation carriers PMID: 21466675
    4. it seems unlikely that any constitutional changes in MRG15 confer an increased risk for breast cancer. PMID: 20844547
    5. gene deficiency reduces DNA repair and increase sensitivity to DNA-crosslinking agents PMID: 20332121
    6. a novel chromodomain protein that is present in two distinct multiprotein complexes involved in transcriptional activation PMID: 12397079
    7. Site-directed mutagenesis studies of a prototypic MRG domain from human MRG15 based on the X-ray structure and bioinformatics identify key residues involved in the binding of PAM14 and MRGBP. PMID: 16407074
    8. identify MRG15 residues that form a shallow hydrophobic pocket to interact with the N-terminal 50 residues of PAM14 through primarily hydrophobic interactions PMID: 17008723
    9. The MRG15 chromo domain may function as an adaptor module which can bind to a modified histone H3 in a mode different from that of the HP1/Pc chromo domains. PMID: 17135209
    10. MORF4 has a role in cellular aging, and MRG15 associates with both histone deacetylases and histone acetyl transferase complexes [review] PMID: 17460191
    11. RBP2 associates with MRG15 complex to maintain reduced H3K4 methylation at transcribed regions, which may ensure the transcriptional elongation state PMID: 17573780
    12. MRG15 is a novel PALB2-interacting factor involved in homologous recombination PMID: 19553677

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 16989

    OMIM: 607303

    KEGG: hsa:10933

    STRING: 9606.ENSP00000331310

    UniGene: Hs.374503