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MLNR Antibody

  • 货号：
    CSB-PA224944
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA224944(MLNR Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    O43193
  • 基因名：
  • 别名：
    MLNR; GPR38; MTLR; MTLR1; Motilin receptor; G-protein coupled receptor 38
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human MLNR
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor for motilin.
  • 基因功能参考文献：
    1. data support important roles of new regions in the TM domains of the motilin receptor for erythromycin action, suggesting differential mechanisms of actions by peptidyl and non-peptidyl ligands PMID: 23142315
    2. The data suggested that in species expressing both motilin-MR and ghrelin-GHSR, there is a compensatory relationship in vivo. PMID: 22465164
    3. The motilin pharmacophore in CHO cells expressing the human motilin receptor PMID: 12054506
    4. motilin receptor extracellular domains have roles in peptide and non-peptidyl agonist binding and activity PMID: 16531413
    5. action by different chemical classes of agonists that are known to interact with distinct regions of the motilin receptor likely yield a common activation state of the cytosolic face of this receptor PMID: 18032475
    6. The motilin receptor is expressed in human colonic and ileal smooth muscle. Further, motilin receptor expression was also shown in the mucosa. PMID: 18183601
    7. Desensitization and internalization of MLNR is independent of the C-terminal tail. PMID: 18420306

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Expressed only in thyroid, stomach, and bone marrow.
  • 数据库链接：

    HGNC: 4495

    OMIM: 602885

    KEGG: hsa:2862

    STRING: 9606.ENSP00000218721

    UniGene: Hs.248126