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METTL1 Antibody

  • 货号：
    CSB-PA013723GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9UBP6
  • 基因名：
  • 别名：
    C12orf1 antibody; D1075 like gene product antibody; FLJ95748 antibody; Methyltransferase like 1 antibody; Methyltransferase like protein 1 antibody; Methyltransferase-like protein 1 antibody; Mettl1 antibody; TRM8 antibody; TRMB_HUMAN antibody; TRMT8 antibody; tRNA (guanine N(7) ) methyltransferase antibody; tRNA (guanine(46)-N(7))-methyltransferase antibody; tRNA (guanine-N(7)-)-methyltransferase antibody; tRNA(m7G46) methyltransferase antibody; tRNA(m7G46)-methyltransferase antibody; YDL201w antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human METTL1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Methyltransferase that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs. Internal N(7)-methylguanine methylation of mRNAs regulates translation. Also methylates a specific subset of miRNAs, such as let-7. N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA). Acts as a regulator of embryonic stem cell self-renewal and differentiation.
  • 基因功能参考文献：
    1. tRNA modifying enzymes, NSUN2 and METTL1, determine sensitivity to 5-fluorouracil in HeLa cells PMID: 25233213
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Class I-like SAM-binding methyltransferase superfamily, TrmB family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 7030

    OMIM: 604466

    KEGG: hsa:4234

    STRING: 9606.ENSP00000314441

    UniGene: Hs.42957