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MAPKBP1 Antibody

  • 中文名称：
    MAPKBP1兔多克隆抗体
  • 货号：
    CSB-PA013476GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O60336
  • 基因名：
    MAPKBP1
  • 别名：
    JNK binding protein 1 antibody; JNK-binding protein 1 antibody; JNKBP-1 antibody; JNKBP1 antibody; KIAA0596 antibody; MABP1_HUMAN antibody; MAPKBP 1 antibody; mapkbp1 antibody; Mitogen activated protein kinase binding protein 1 antibody; Mitogen-activated protein kinase-binding protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human MAPKBP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response. Involved in JNK signaling pathway.
  • 基因功能参考文献：
    1. We identified mutations in MAPKBP1 as a genetic cause of juvenile or late-onset and cilia-independent nephronophthisis. PMID: 28089251
    2. JNKBP1 and NOD2 are co-expressed in the human intestinal epithelium and in immune cells recruited in the lamina propria, which suggests that JNKBP1 contributes to maintain NOD2-mediated intestinal immune homeostasis. PMID: 22700971
  • 相关疾病：
    Nephronophthisis 20 (NPHP20)
  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle pole.
  • 组织特异性：
    Expressed in intestinal mucosa, where it is detected in epithelial cells, endothelial cells, smooth muscle cells and immune cells, such as lymphocytes. Expressed in kidney.
  • 数据库链接：

    HGNC: 29536

    OMIM: 616786

    KEGG: hsa:23005

    STRING: 9606.ENSP00000393099

    UniGene: Hs.513661