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MAP3K12 Antibody

  • 货号：
    CSB-PA143673
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA143673(MAP3K12 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA143673(MAP3K12 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q12852
  • 基因名：
  • 别名：
    Dlk antibody; Dual leucine zipper bearing kinase antibody; Dual leucine zipper kinase DLK antibody; Leucine-zipper protein kinase antibody; M3K12_HUMAN antibody; Map3k12 antibody; MAPK-upstream kinase antibody; MEKK12 antibody; Mitogen-activated protein kinase kinase kinase 12 antibody; Mixed lineage kinase antibody; MUK antibody; Protein kinase MUK antibody; ZPK antibody; ZPKP1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human MAP3K12
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:15-1:50
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Part of a non-canonical MAPK signaling pathway. Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1. May be an activator of the JNK/SAPK pathway.
  • 基因功能参考文献：
    1. LZK cooperates with DLK to promote retinal ganglion cell death in response to axon injury. PMID: 28641113
    2. REVIEW: Regulation of Beta-Cell Function and Mass by the Dual Leucine Zipper Kinase PMID: 27100796
    3. miR-130a inhibited the JNK pathway by targeting MAP3K12, contributing to its anti-apoptotic effect and the maintenance of diabetic endothelial progenitor cell function. PMID: 25999017
    4. Data suggest that specific pharmacological inhibition of dual leucine zipper kinase (DLK, MAP3K12) may have therapeutic potential in multiple indications of neuronal degeneration. PMID: 25341110
    5. these findings indicate that DLK participates in cell proliferation and/or survival, at least in part, by modulating the expression of cell cycle regulatory proteins. PMID: 21893036
    6. The results confirm the significance of apoptosis deregulation in CLL, and suggest a possible relationship between ZIPK expression and the clinical course of the disease. PMID: 21526495
    7. the DLK-ERK signaling pathway may act as a regulator of the interaction that occurs between Hsp27 and the cytoskeleton during the formation of the cornified cell envelope, a process conferring to the skin its crucial barrier function PMID: 19675578
    8. for the selective expression of ZPK gene, cell-specific negative regulatory element(s) which locate outside of the core promoter region repress the potent basic promoter activity PMID: 14697235
    9. ZIPK is positively regulated by phosphorylation within its kinase domain and contains an inhibitory C-terminal domain that controls enzyme activity. PMID: 15611134
    10. DLK is a signaling molecule implicated in the regulation of keratinocyte terminal differentiation and cornification PMID: 15695824
    11. DAPK-ZIPK-L13a axis forms a unique regulatory module that first represses, then repermits inflammatory gene expression. PMID: 18995835
    12. Src-dependent tyrosine phosphorylation recombinant human DLK was important for regulation of its activity. DLK may have a role in PDGF signaling. PMID: 19146952

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  • 亚细胞定位：
    Cytoplasm. Cell membrane.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
  • 组织特异性：
    Highly expressed in brain and kidney.
  • 数据库链接：

    HGNC: 6851

    OMIM: 600447

    KEGG: hsa:7786

    STRING: 9606.ENSP00000448689

    UniGene: Hs.713539