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LY86 Antibody

  • 货号：
    CSB-PA013252ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA013252ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA013252ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LY86 Polyclonal antibody
  • Uniprot No.：
    O95711
  • 基因名：
    LY86
  • 别名：
    BPAD antibody; dJ80N2.1 antibody; Ly 86 antibody; Ly-86 antibody; Ly86 antibody; LY86_HUMAN antibody; Lymphocyte antigen 86 antibody; Lymphocyte antigen 86 precursor antibody; Major affective disorder 1 antibody; MD 1 antibody; MD-1 antibody; MD1 protein antibody; MD1 RP105 associated antibody; MMD 1 antibody; MMD-1 antibody; Protein MD 1 antibody; Protein MD-1 antibody; RP1-80N2.1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Lymphocyte antigen 86 protein (21-162AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression.
  • 基因功能参考文献：
    1. our results reveal that MD-1 deficiency is of critical importance in down-regulating induction and progression of colitis, thereby suggesting that MD-1 might be a target for future interventional therapies of inflammatory bowel disease. PMID: 27209086
    2. DNA methylation of the LY86 gene is associated with obesity, insulin resistance, and inflammation. PMID: 24735745
    3. MD-1 may be a disease susceptibility gene for adult asthma in a Southern Han population in China. PMID: 21426727
    4. Both mouse and human RP105/MD-1 exhibit dimerization of the 1:1 RP105/MD-1 complex, demonstrating a novel organization. PMID: 21959264
    5. In this study, we produced variants of MD-1 and MD-2 in Pichia pastoris. Contrary to previous reports, this study suggests that MD-1 can bind to LPS. PMID: 21130168
    6. in the promoter region we identified 3 SNPs, rs1334710, rs4959389 and rs977785 that are associated with mite-sensitive allergy in Taiwanese children; results suggested that MD-1 could be a susceptible gene for mite-sensitive allergy in Taiwanese children PMID: 18001295
    7. Identified MD-1 SNP (rs7740529) association with asthma in Taiwanese children and adults. PMID: 19255686

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  • 亚细胞定位：
    Secreted, extracellular space. Note=Associated with CD180 at the cell surface.
  • 组织特异性：
    Highly expressed in B-cells, monocytes and tonsil.
  • 数据库链接：

    HGNC: 16837

    OMIM: 605241

    KEGG: hsa:9450

    STRING: 9606.ENSP00000230568

    UniGene: Hs.653138