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LPO Antibody

  • 货号：
    CSB-PA013066LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA013066LA01HU diluted at 1:300 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Western Blot
      Positive WB detected in: K562 whole cell lysate, HL60 whole cell lysate
      All lanes: LPO antibody at 5.1μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 81, 71 kDa
      Observed band size: 81 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LPO Polyclonal antibody
  • Uniprot No.：
    P22079
  • 基因名：
    LPO
  • 别名：
    LPO antibody; SAPX antibody; Lactoperoxidase antibody; LPO antibody; EC 1.11.1.7 antibody; Salivary peroxidase antibody; SPO antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Lactoperoxidase protein (81-190AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，LPO Antibody (CSB-PA013066LA01HU)，的标记方式是Non-conjugated。对于LPO Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA013066LB01HU LPO Antibody, HRP conjugated ELISA
    FITC CSB-PA013066LC01HU LPO Antibody, FITC conjugated
    Biotin CSB-PA013066LD01HU LPO Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN). May contribute to airway host defense against infection.
  • 基因功能参考文献：
    1. The crystal structure of the complex of LPO with MZY showed that MZY bound to LPO in the substrate-binding site on the distal heme side. MZY was oriented in the substrate-binding site in such a way that the sulfur atom is at a distance of 2.58 A from the heme iron PMID: 28653416
    2. LPO mRNA was undetectable in the gastric mucosa. PMID: 27048452
    3. Oral peroxidase activity as a marker of chronic alcohol abuse may help in the diagnosis of alcoholism. PMID: 23042278
    4. establish urate as a likely physiological substrate for LPO that will influence host defense and give rise to reactive electrophilic metabolites PMID: 24928513
    5. High intensity of caries is associated with increased levels of some salivary components - sIgA, histatin-5 and lactoperoxidase. PMID: 24974109
    6. a functional LPO system exists in human airways and may contribute to airway host defense against infection PMID: 12626341
    7. lactoperoxidase may play an important role in the metabolic events associated with Parkinson's disease PMID: 15384204
    8. Analysis of the role of thiocyanate (SCN-), in modulating the catalytic activity of myeloperoxidase (MPO) and other members of the lactoperoxidase (LPO) and eosinophil peroxidase (EPO) PMID: 15894800
    9. Splice variants may contribute to LPO molecular heterogeneity and its regulation by intracellular compartmental localization in respiratory epithelium. PMID: 19059195

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Peroxidase family, XPO subfamily
  • 组织特异性：
    Mammary gland; milk and salivary gland. Found in bronchial submucosal glands.
  • 数据库链接：

    HGNC: 6678

    OMIM: 150205

    KEGG: hsa:4025

    STRING: 9606.ENSP00000262290

    UniGene: Hs.234742