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LGI4 Antibody

  • 货号：
    CSB-PA818678LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA818678LA01HU diluted at 1:200 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA818678LA01HU diluted at 1:200 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LGI4 Polyclonal antibody
  • Uniprot No.：
    Q8N135
  • 基因名：
    LGI4
  • 别名：
    Leucine rich glioma inactivated gene 4 antibody; Leucine rich glioma inactivated protein 4 antibody; Leucine rich repeat LGI family member 4 antibody; Leucine-rich glioma-inactivated protein 4 antibody; Leucine-rich repeat LGI family member 4 antibody; LGI1 like protein 3 antibody; LGI1-like protein 3 antibody; LGI4 antibody; Lgi4 protein antibody; LGI4_HUMAN antibody; Lgil3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Leucine-rich repeat LGI family member 4 protein (292-412AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，LGI4 Antibody (CSB-PA818678LA01HU)，的标记方式是Non-conjugated。对于LGI4 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA818678LB01HU LGI4 Antibody, HRP conjugated ELISA
    FITC CSB-PA818678LC01HU LGI4 Antibody, FITC conjugated
    Biotin CSB-PA818678LD01HU LGI4 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation.
  • 基因功能参考文献：
    1. in four unrelated multiplex families presenting with severe arthrogryposis multiplex congenital, identified biallelic loss-of-function mutations in LGI4; functional tests showed these germline mutations caused aberrant splicing of the endogenous LGI4 transcript and in a cell-based assay impaired the secretion of truncated LGI4 protein PMID: 28318499
    2. Intratumoral heterogeneity of ADAM23 promotes tumor growth and metastasis through LGI4 and nitric oxide signals. PMID: 24662834
    3. The positive genotypic association between benign familial infantile convulsions (BFIC)and c.1722G/A polymorphism suggests that LGI4 might contribute to the susceptibility to BFIC. PMID: 19815358
    4. Schwann cells are the principal cellular source of Lgi4 in the developing nerve; transgenic Lgi4 binds directly to Adam22 without a requirement for additional membrane associated factors. PMID: 20220021
    5. Screening of the LGI4 coding region in BFIC and childhood absence epilepsy (CAE) revealed several frequent exonic polymorphisms. PMID: 14505228

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  • 相关疾病：
    Arthrogryposis multiplex congenita, neurogenic, with myelin defect (AMCNMY)
  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Widely expressed, with highest expression in brain.
  • 数据库链接：

    HGNC: 18712

    OMIM: 608303

    KEGG: hsa:163175

    STRING: 9606.ENSP00000312273

    UniGene: Hs.65256