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  4. KLK13 Antibody

KLK13 Antibody

  • 货号：
    CSB-PA185718
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA185718(KLK13 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA185718(KLK13 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9UKR3
  • 基因名：
    KLK13
  • 别名：
    DKFZp586J1923 antibody; Kalikrein antibody; Kallikrein 13 antibody; Kallikrein L4 antibody; Kallikrein Like 4 antibody; Kallikrein like 4 variant included antibody; Kallikrein like gene 4 antibody; Kallikrein like protein 4 antibody; Kallikrein related peptidase 13 antibody; Kallikrein-13 antibody; Kallikrein-like protein 4 antibody; KLK-L4 antibody; KLK13 antibody; KLK13_HUMAN antibody; KLKL 4 antibody; KLKL4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human KLK13
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Relatively high levels of KLK13 expression in ESCC were associated with cell proliferation and correlated with tumor progression, advanced cancer stage, and poor prognosis PMID: 29582368
    2. Decreased KLK13 mRNA levels correlate with poor survival in esophageal squamous cell carcinoma patients. PMID: 29221724
    3. There was no significant association of KLK13 and KLK14 mRNA expression with the clinical factors ascitic fluid volume or residual tumor mass. In univariate Cox regression analysis, elevated KLK13 mRNA levels were significantly linked with shorter progression-free (PFS; hazard ratio [HR] = 1.97, P = 0.020) and overall survival (OS; HR = 1.81, P = 0.041). PMID: 29546479
    4. This first clinical study of KLK13 in bladder cancer reveals its deregulated expression in bladder tumors and highlights KLK13 as a promising marker for improving TaT1 patients' prognosis following treatment. PMID: 27858162
    5. Our results suggest that KLK13 mRNA expression constitutes a novel biomarker for the prediction of overall survival in nonsmall cell lung cancer and that its quantitative assessment in tumor tissues can aid in treatment decision making. PMID: 25677900
    6. KLK13 may play an important role in regulating cellular migration and invasiveness, making the loss of KLK13 a potential biomarker for early detection of lymph node metastasis in oral squamous cell carcinomas. PMID: 23371469
    7. Data indicate that five out of 9 SNPs in the KLK13 gene were associated with prostate cancer risk and/or aggressiveness. PMID: 21741862
    8. High KLK13 expression is associated with drug response in gastric cancer. PMID: 22948777
    9. Results indicate that KLK13 may play a role in the defense of the upper digestive apparatus and in male reproductive organs. PMID: 21689719
    10. Serine protease of Kazal-type (SPINK6) expressed in normal human skin is a potent natural inhibitor of Kallikrein-related peptidases, KLK12 and KLK13. PMID: 21439340
    11. these results reveal the enhancing effects of KLK13 on tumor cell invasion and migration, and that it may serve as a diagnostic/prognostic marker and a potential therapeutic target for lung cancer. PMID: 21596022
    12. This is the first study disclosing the possible clinical utility of KLK13 as a new tumor biomarker capable of predicting a favorable outcome for gastric cancer patients. PMID: 20678496
    13. KLK13 expression is an independent favorable prognostic marker for breast carcinoma PMID: 11986781
    14. kallikrein 13 is expressed in the nonmalignant and malignant prostate, with cancer tissues demonstrating slightly lower expression PMID: 12970725
    15. hK13 interacts and forms complexes with serum protease inhibitors, including alpha2-macroglobulin, alpha1-antichymotrypsin and alpha2-antiplasmin PMID: 14687906
    16. Human kallikrein13 may play a role in tissue remodeling and/or tumor invasion and metastasis. PMID: 15381110
    17. hK13 is expressed in several common salivary gland tumors PMID: 16847813
    18. non-small-cell lung cancer patients with high KLK13 expression at the mRNA or protein level had lower overall survival PMID: 18627302
    19. KLK6 and KLK13 predict tumor recurrence in epithelial ovarian carcinoma. PMID: 19707197

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase S1 family, Kallikrein subfamily
  • 组织特异性：
    Expressed in prostate, breast, testis and salivary gland.
  • 数据库链接：

    HGNC: 6361

    OMIM: 605505

    KEGG: hsa:26085

    STRING: 9606.ENSP00000470555

    UniGene: Hs.165296