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KLF8 Antibody

  • 货号：
    CSB-PA006805
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    O95600
  • 基因名：
    KLF8
  • 别名：
    Basic krueppel-like factor 3 antibody; BKLF3 antibody; DXS741 antibody; KLF8 antibody; KLF8_HUMAN antibody; Krueppel-like factor 8 antibody; Kruppel like factor 8 antibody; MGC138314 antibody; Zinc finger protein 741 antibody; ZNF741 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human KLF8.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK).
  • 基因功能参考文献：
    1. High KLF8 expression is associated with breast cancer cell invasion, transendothelial migration and metastasis. PMID: 26993780
    2. expression of miR-1236-3p was lower in lung adenocarcinoma tissues than that in adjacent normal tissue; in A549 cell line, miR-1236-3p decreased ability of cell invasion and migration; furthermore, KLF8 is targeted by miR-1236-3p, and expression of miR-1236-3p is negatively correlated with KLF8; additionally, miR-1236-3p suppressed the expression of KLF8 and EMT (epithelial mesenchymal transition)-related genes PMID: 28842254
    3. Overexpression of KLF8 may contribute to the progression of pancreatic cancer, and downregulation of KLF8 expression by lentivirus-delivered shRNA is a novel therapeutic approach for PC. PMID: 26995652
    4. KLF8 plays a crucial role in proliferation and migration of bladder cancer cells PMID: 25323066
    5. KLF8-induced FHL2 activation is a novel and critical signaling mechanism underlying human colorectal cancer invasion and metastasis. PMID: 26320172
    6. KLF8 and miR141/EGFR have roles in signaling pathway potentially crucial for breast cancer malignancy PMID: 26025929
    7. KLF8 suppression induced cell differentiation and inhibited tumorigenesis in colorectal cancer PMID: 26133391
    8. MiR-135a inhibits migration and invasion and regulates epithelial-mesenchymal transition-related marker genes by targeting KLF8 in lung cancer cells. PMID: 26235874
    9. KLF8 is a novel epithelial to mesenchymal transition regulating transcription factor that involved in the progression of gastric cancer. PMID: 25333643
    10. In this review, we focus on the functions, roles, and regulatory networks of these five KLFs in HCC, summarize key pathways, and propose areas for further investigation PMID: 25652467
    11. A novel KLF8 to EPSTI1 to VCP to NF-kappaB signaling mechanism potentially critical for breast cancer invasion and metastasis. PMID: 24096480
    12. KLF8 is involved in hypoxia-induced multidrug resistance through inhibiting apoptosis and increasing the drug release rate by directly regulating MDR1 transcription. PMID: 25040744
    13. Positive nuclear KLF8 might be correlated with lower survival in gastric adenocarcinoma patients and might be an oncogene property in gastric adenocarcinoma carcinogenesis. PMID: 24461703
    14. KLF8 knockdown suppresses proliferation and invasion in human osteosarcoma cells. PMID: 24604387
    15. KLF8 and FAK cooperatively enrich the active MMP14 on the cell surface required for the metastatic progression of breast cancer. PMID: 23812425
    16. Hypoxia-reoxygenation reduces the expression and nuclear localization of KLF8 to inhibit the trophoblast invasion by downregulating MMP-9 levels. PMID: 23703536
    17. KLF8 overexpression is an important factor in human ovarian carcinoma pathogenesis. PMID: 23222713
    18. KLF8 is closely associated with gastric tumor progression, angiogenesis and poor prognosis PMID: 23885141
    19. High KLF8 methylation was associated with biochemical recurrence in prostate cancer. PMID: 23918943
    20. With pull down assay and co-immunoprecipitation assay, the study demonstrated that KLF8 bound directly to AR, and KLF8 enhanced AR target gene transcription in human prostate cancer cells. PMID: 23023312
    21. Data show that TGF-beta1 regulates E-cadherin and vimentin expression through KLF8 pathway. PMID: 23504025
    22. a novel role and mechanism for KLF8 in the regulation of DNA repair and therapeutic resistance in breast cancer cells. PMID: 23105099
    23. KLF8 is necessary for cell survival and invasion in gastric cancer cells. PMID: 22766838
    24. Knockdown of beta-catenin by shRNA rescues the enhanced HepG2 and Hep3B cells proliferation ability induced by overexpression of KLF8 PMID: 22761862
    25. Kruppel-like factor 8 (KLF8) is expressed in gliomas of different WHO grades and is essential for tumor cell proliferation. PMID: 22276196
    26. PARP-1 as a novel KLF8-binding and -regulating protein and provided new insights into the mechanisms underlying the regulation of KLF8 nuclear localization, stability, and functions. PMID: 21518760
    27. Immunohistochemical staining strongly correlated the co-expression of KLF8 and MMP9 with the patient tumor invasion, metastasis and poor survival PMID: 21151179
    28. KLF8 promotes hepatocellular carcinoma cell proliferation and invasion, inhibits apoptosis, and induces the epithelial-to-mesenchymal transition PMID: 20728449
    29. KLF8 is possibly involved in regulating cell growth, invasion, apoptosis, and proliferation of renal carcinoma cancer; blocking this protein may be a therapeutic strategy for this cancer. PMID: 20182889
    30. The gene KLF8 is abnormally expressed in a female patient with X;autosome translocation t(X;21)(p11.2;q22.3) and non-syndromic mental retardation. PMID: 11836360
    31. Over expression of KLF8 is associated with cancer PMID: 16832343
    32. Functional studies using RNA interference revealed that the silencing of Sp1 and KLF8 resulted in elevated level of gamma globin expression in K562 cells. PMID: 17224162
    33. Overexpression of Kruppel-like factor 8 is associated with epithelial to mesenchymal transition and epithelial cell invasion leading to breast cancer PMID: 17671186
    34. FAK induces KLF8 expression in human ovarian cancer cells by activating the PI3K-Akt signaling pathway, leading to the activation of KLF8 promoter by Sp1 PMID: 18353772

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Sp1 C2H2-type zinc-finger protein family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 6351

    OMIM: 300286

    KEGG: hsa:11279

    STRING: 9606.ENSP00000417303

    UniGene: Hs.646614