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KIF4A Antibody

  • 货号：
    CSB-PA266335
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from HeLa cells, using KIF4A antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) KIF4A Polyclonal antibody
  • Uniprot No.：
    O95239
  • 基因名：
    KIF4A
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human KIF4A.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis. Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization.
  • 基因功能参考文献：
    1. High KIF4A expression is associated with lung cancer. PMID: 28160558
    2. decrease in Aurora B results in diminished binding of the chromokinesin Kif4A to chromosome arms. PMID: 28821562
    3. Neither KIF4A nor condensin I alone can sufficiently accumulate on the chromosomal axis and confer physiological properties to chromosomes, thus establishing that the functions of KIF4A and condensin I are inseparable PMID: 27633014
    4. Chromokinesin represents a kinesin superfamily regulating cell division through chromosome and spindle. (Review) PMID: 27196062
    5. Hepatitis B virus activates the KIF4A gene promoter and upregulates the mRNA and protein expression of KIF4A. PMID: 25998931
    6. KIF4A and PP2A-B56G and -B56E create a spatially restricted negative feedback loop counteracting Aurora B in anaphase. PMID: 25512391
    7. KIF4A might be a key regulator for tumoral progression in OSCCs. PMID: 24386490
    8. Genetic association of KIF4A and KIF5C mutations in intellectual disability and synaptic function. PMID: 24812067
    9. The KIF4A phosphorylation by Aurora B stimulates the maximal microtubule-dependent ATPase activity of KIF4A and promotes its interaction with PRC1. PMID: 23940115
    10. Studies reveal how interactions between the conserved nonmotor MAP, PRC1, and the motor protein, kinesin-4, generate filament length-dependent tags at microtubule plus ends. PRC1 tags ends of microtubules in dividing cells and the size of these tags increases linearly with filament length. PMID: 23870126
    11. KIF4 regulates midzone length during cytokinesis. PMID: 21565503
    12. Loss of KIF4 expression is associated with gastric carcinoma. PMID: 20711700
    13. Results demonstrating association of KIF4 with BRAF35 through the interaction of their respective alpha-helical coiled-coil domains is unique so far in mammals. PMID: 12809554
    14. These results suggest that KIF4 is involved in cytokinesis, although direct evidence was not provided in this study. PMID: 15031677
    15. KIF4 and its binding partner protein regulator of cytokinesis 1 play essential roles in the organization of central spindles and midzone formation PMID: 15297875
    16. Human KIF4A is an essential chromosome-associated molecular motor involved in faithful chromosome segregation. HKIF4A localizes in the nucleoplasm during interphase and on condensed chromosome arms during mitosis. PMID: 15326200
    17. role of PRC1 in midzone formation, indicate that cell cycle-dependent translocation of PRC1 by Kif4 is essential for midzone formation and cytokinesis. PMID: 15625105
    18. Zip1 and CR motifs are important for Kif4A chromatin-binding and its mitotic function. PMID: 18502200
    19. results suggest a novel role for a chromokinesin family member Kif4 in the DNA damage response by modulating the BRCA2/Rad51 pathway PMID: 18604178
    20. These studies identify a novel transit station through which Gag traffics en route to particle assembly and highlight the importance of KIF4 in regulating HIV-1 Gag trafficking and stability. PMID: 18684836

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  • 亚细胞定位：
    Nucleus matrix. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Midbody. Chromosome.
  • 蛋白家族：
    TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, Chromokinesin subfamily
  • 组织特异性：
    Highly expressed in hematopoietic tissues, fetal liver, spleen, thymus and adult thymus and bone marrow. Lower levels are found in heart, testis, kidney, colon and lung.
  • 数据库链接：

    HGNC: 13339

    OMIM: 300521

    KEGG: hsa:24137

    STRING: 9606.ENSP00000363524

    UniGene: Hs.648326