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KCNE4 Antibody

  • 中文名称：
    KCNE4兔多克隆抗体
  • 货号：
    CSB-PA012029GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8WWG9
  • 基因名：
    KCNE4
  • 别名：
    KCNE4 antibody; Potassium voltage-gated channel subfamily E member 4 antibody; MinK-related peptide 3 antibody; Minimum potassium ion channel-related peptide 3 antibody; Potassium channel subunit beta MiRP3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human KCNE4
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.
  • 基因功能参考文献：
    1. The KCNE1 (rs1805127) appears to an independent risk factor for AF in the Uygur population. And the KCNE4 (rs12621643) was an independent risk factor for AF among both Uygurs and Hans. PMID: 28981946
    2. the tertiary structure of the C-terminal domain of Kv1.3 is necessary and sufficient for Kv1.3- KCNE4 interaction. PMID: 27802162
    3. the association of the KCNE4 gene variability with allergic rhinitis PMID: 23866632
    4. KCNE4 juxtamembrane region is required for interaction with calmodulin and for functional suppression of KCNQ1. PMID: 21118809
    5. MiRP3 modulates Kv4.2 current activation, inactivation and recovery from inactivation. MiRP3 shifts the half-maximal voltage for activation and slows time to peak ~ 100%. PMID: 20498229
    6. KCNE4 E145D polymorphism may be related to atrial fibrillation. PMID: 16563243
    7. KCNE4 (potassium voltage-gated channel subfamily E member 4), but not KCNE2, functions as an inhibitory Kv1.3 partner in leukocytes. PMID: 19773357
    8. expressed strongly in heart, skeletal muscle, and kidney, less in placenta, lung, and liver, and weakly in brain and blood cells. Electrophysiological study showed that KCNE4 modulates the activation of the KCNQ1 channel. PMID: 12670483
    9. KCNE4 beta-subunit has a drastic inhibitory effect on currents generated by Kv1.1 and Kv1.3 potassium channels PMID: 12944270
    10. Based upon previous studies and the present results, it is concluded that both hKCNE4 and mKCNE4 have a drastic inhibitory impact on both hKCNQ1 and mKCNQ1 currents. PMID: 15707997
    11. The non-synonymous single nucleotide polymorphism E145D may be associated with the atrial fibrillation phenotype. PMID: 17016049
    12. KCNE4 directly associates with KCNQ1, and can co-associate together with KCNE1 in the same KCNQ1 complex to form a 'triple subunit' complex (KCNE1-KCNQ1-KCNE4). PMID: 18279388
    13. MiRP3 (encoded by the KCNE4 gene) plays a role in modulation of BK-dependent urinary potassium excretion. PMID: 18463315
    14. Specific KCNE4 domains responsible for the inhibitory effects on heterologously expressed KCNQ1 were identified. The KCNE4 C-terminus is critical for KCNQ1 modulation and physically interacts with KCNQ1. PMID: 19029186

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  • 亚细胞定位：
    Membrane; Single-pass membrane protein.
  • 蛋白家族：
    Potassium channel KCNE family
  • 组织特异性：
    Predominantly expressed in embryo and adult uterus. Low expression found in kidney, small intestine, lung and heart.
  • 数据库链接：

    HGNC: 6244

    OMIM: 607775

    KEGG: hsa:23704

    STRING: 9606.ENSP00000281830

    UniGene: Hs.348522