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KCNE3 Antibody

  • 货号：
    CSB-PA22569A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA22569A0Rb diluted at 1:200 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA22569A0Rb diluted at 1:200 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA22569A0Rb at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) KCNE3 Polyclonal antibody
  • Uniprot No.：
    Q9Y6H6
  • 基因名：
    KCNE3
  • 别名：
    KCNE3 antibody; Potassium voltage-gated channel subfamily E member 3 antibody; MinK-related peptide 2 antibody; Minimum potassium ion channel-related peptide 2 antibody; Potassium channel subunit beta MiRP2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Potassium voltage-gated channel subfamily E member 3 protein (1-57AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，KCNE3 Antibody (CSB-PA22569A0Rb)，的标记方式是Non-conjugated。对于KCNE3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA22569B0Rb KCNE3 Antibody, HRP conjugated ELISA
    FITC CSB-PA22569C0Rb KCNE3 Antibody, FITC conjugated
    Biotin CSB-PA22569D0Rb KCNE3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship.
  • 基因功能参考文献：
    1. Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4 has been reported. PMID: 27922120
    2. Structural, computational, biochemical, and electrophysiological studies lead to an atomically explicit integrative structural model of the KCNE3-KCNQ1 complex that explains how KCNE3 induces the constitutive activation of KCNQ1 channel activity, a crucial component in K(+) recycling. PMID: 27626070
    3. Reported here are previously undiscovered protein-coding regions in exon 1 of hKCNE3 and hKCNE4 that extend their encoded extracellular domains by 44 and 51 residues, which yields full-length proteins of 147 and 221 residues, respectively. PMID: 27162025
    4. Based on current evidence from published studies, neither of the two variants from KCNE was significantly associated with the risk of Meniere's disease--{REVIEW} PMID: 26890422
    5. Data show that voltage-gated potassium channel KCNE3 directly affects the S4 movement in potassium channel KCNQ1. PMID: 26668384
    6. KCNQ1/KCNE3 channels make only a small contribution to basolateral conductance in normal colonic crypts, with increased channel activity in UC appearing insufficient to prevent colonic cell depolarization in this disease. PMID: 26718405
    7. KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation PMID: 26410412
    8. A KCNE3 T4A mutation was identified in a Japanese patient presenting Brugada-pattern ECG and neurally mediated syncope. PMID: 22987075
    9. Allele frequencies are studied for 11 known variants of KCNE3 gene, of which two (F66F and R83H) are polymorphic but are not associated with chronic tinnitus. PMID: 21899751
    10. The results of this study indicated that Kv7.5 contributes to the spatial regulation. PMID: 22190306
    11. 2 of the 8 MiRP2 extracellular domain acidic residues (D54 and D55) are important for KCNQ1-MiRP2 constitutive activation. PMID: 20040519
    12. data show that SNPs in KCNE1 and KCNE3 are not associated with Meniere disease in Caucasians PMID: 20034061
    13. The KCNE3 protein within the micellesis in monomeric form and acquires mainly alpha-helical conformation. PMID: 19961415
    14. Ectopic expression of KCNE3 accelerates cardiac repolarization and abbreviates the QT interval. PMID: 11956246
    15. The s found MiRP2-R83H in 3 of 321 control subjects and in 5 unaffected related individuals. Provocation of an unaffected carrier with glucose or KCl did not induce weakness. PMID: 15037716
    16. interaction of MiRP2-72 with KCNQ1-338; and MinK-59,58 with KCNQ1-339, 340 PMID: 16308347
    17. The result indicates that 112G/A SNP in the KCNE1 gene and 198T/C SNP in the KCNE3 gene could determine an increased susceptibility to develop MD. PMID: 16374062
    18. The characterization of a missense mutation in MiRP2 that affects its phosphorylation and consequent interactions with Kv3.4 is reported. PMID: 16449802
    19. KCNE3 also inhibits currents generated by Kv4.3 in complex with the accessory subunit KChIP2 PMID: 16782062
    20. Up-regulation and incrased activity of KV3.4 channels and their accessory subunit Mirp2 induced by amyloid peptide are involved in apoptotic neuronal death. PMID: 17495071
    21. Abnormalities in the KCNE3 gene is a potential genetic risk factor for initiation and/or maintenance of atrial fibrillation. PMID: 18209471
    22. KCNE3 plays a functional role in the modulation of I(to) in the human heart and suggest that mutations in KCNE3 can underlie the development of BrS. PMID: 19122847

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cytoplasm. Perikaryon. Cell projection, dendrite. Membrane raft.
  • 蛋白家族：
    Potassium channel KCNE family
  • 组织特异性：
    Expressed in hippocampal neurons (at protein level). Widely expressed with highest levels in kidney and moderate levels in small intestine.
  • 数据库链接：

    HGNC: 6243

    OMIM: 604433

    KEGG: hsa:10008

    STRING: 9606.ENSP00000310557

    UniGene: Hs.523899