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ITGA8 Antibody

  • 货号：
    CSB-PA011871NA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA011871NA01HU diluted at 1:500 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ITGA8 Polyclonal antibody
  • Uniprot No.：
    P53708
  • 基因名：
  • 别名：
    Integrin alpha 8 antibody; Integrin alpha-8 heavy chain antibody; Integrin alpha-8 light chain antibody; ITA8_HUMAN antibody; ITGA 8 antibody; ITGA8 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Peptide sequence from Human Integrin alpha-8 protein (114-131AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ITGA8 Antibody (CSB-PA011871NA01HU)，的标记方式是Non-conjugated。对于ITGA8 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA011871NB01HU ITGA8 Antibody, HRP conjugated ELISA
    FITC CSB-PA011871NC01HU ITGA8 Antibody, FITC conjugated
    Biotin CSB-PA011871ND01HU ITGA8 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
  • 基因功能参考文献：
    1. ITGA2B and ITGA8 have roles in prognosis in clear cell renal cell carcinoma patients PMID: 26198048
    2. In 15 of 590 families, we identified recessive mutations in the genes FRAS1, FREM2, GRIP1, FREM1, ITGA8, and GREM1, all of which function in the interaction of the ureteric bud and the metanephric mesenchyme. PMID: 24700879
    3. Mutations of ITGA8 are a genetic cause of bilateral renal agenesis and that, at least in some cases, bilateral renal agenesis is an autosomal-recessive disease. PMID: 24439109
    4. the ITGA8 gene might have gender-specific roles in the development of schizophrenia. PMID: 23153507
    5. Analysis of the data demonstrated that Itga8 expression is CArG box-serum response factor independent, but myocardin dependent through an as yet unknown sequence module that is distal from the promoter region. PMID: 23142384
    6. The mRNA levels of Integrinalpha8 were significantly lower in LSCC tissues than that in corresponding adjacent normal tissues. PMID: 20942236
    7. alpha8beta1 is a prerequisite for the proper conduct of anoikis in normal human intestinal epithelial crypt cells, whereas its loss contributes to the illicit acquisition of anoikis resistance. PMID: 20678483
    8. expressed in developing kidney PMID: 12060755
    9. Role in regulation of mesangial cell phenotype. Seems to promote adhesion, but inhibit migration and proliferation of mesangial cells. Alpha8 integrin could play important role in maintaining tissue integrity in glomerulus during glomerular injury. PMID: 12787402
    10. genomic analysis of the human integrin subunit alpha8 gene PMID: 15579315
    11. Mammary carcinoma cells do express alpha8 integrin. PMID: 15592496
    12. A polymorphism of the ITGA8 promoter modifies the progression of renal failure in ADPKD. PMID: 18277079
    13. These results indicate that the specific high-affinity binding of nephronectin to alpha8beta1 integrin is achieved by bipartite interaction of the integrin with the RGD motif and LFEIFEIER sequence. PMID: 19342381
    14. In intestinal crypt cells, integrin alpha8beta1 is closely involved in the regulation of adhesion, migration and cell proliferation via a predominant RhoA/ROCK-dependent mechanism. PMID: 19527220

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  • 相关疾病：
    Renal hypodysplasia/aplasia 1 (RHDA1)
  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein. Cell membrane.
  • 蛋白家族：
    Integrin alpha chain family
  • 组织特异性：
    Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level).
  • 数据库链接：

    HGNC: 6144

    OMIM: 191830

    KEGG: hsa:8516

    STRING: 9606.ENSP00000367316

    UniGene: Hs.171311