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ISX Antibody

  • 货号：
    CSB-PA011854LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA011854LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human glioma using CSB-PA011854LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ISX Polyclonal antibody
  • Uniprot No.：
    Q2M1V0
  • 基因名：
    ISX
  • 别名：
    DKFZp781N2395 antibody; Intestine-specific homeobox antibody; Isx antibody; ISX_HUMAN antibody; MGC138417 antibody; OTTHUMP00000028558 antibody; Pancreas intestine homeodomain transcription factor antibody; Pix 1 antibody; RAX like homeobox antibody; RAX-like homeobox antibody; RAXLX antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Intestine-specific homeobox protein (1-245AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ISX Antibody (CSB-PA011854LA01HU)，的标记方式是Non-conjugated。对于ISX Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA011854LB01HU ISX Antibody, HRP conjugated ELISA
    FITC CSB-PA011854LC01HU ISX Antibody, FITC conjugated
    Biotin CSB-PA011854LD01HU ISX Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCO1 expression in the intestine.
  • 基因功能参考文献：
    1. our results indicate that E2F1 is an important downstream gene of ISX in hepatoma progression. PMID: 27175585
    2. Results show that ISX expression mediated AHR-induced tumorigenesis in hepatocellular carcinoma. PMID: 28398627
    3. Overall, our results identified a feed-forward mechanism of immune suppression in hepatocellular carcinoma organized by ISX, which involves kynurenine-AHR signaling and PD-L1, offering insights into immune escape by hepatocellular carcinoma PMID: 28625979
    4. ISX expression induced by H. pylori infection may lead to intestinal metaplasia and hyperproliferation of gastric mucosa through CDX1/2 and cyclinD1 expression, contributing to gastric carcinogenesis. PMID: 26872890
    5. Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX PMID: 23393141
    6. our results highlight ISX as an important regulator in hepatoma progression with significant potential as a prognostic and therapeutic target in HCCs. PMID: 23221382

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 28084

    OMIM: 612019

    KEGG: hsa:91464

    STRING: 9606.ENSP00000311492

    UniGene: Hs.567637