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INCA1 Antibody

  • 货号：
    CSB-PA605764LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA605764LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) INCA1 Polyclonal antibody
  • Uniprot No.：
    Q0VD86
  • 基因名：
    INCA1
  • 别名：
    HSD45 antibody; Inca1 antibody; INCA1_HUMAN antibody; Inhibitor of CDK cyclin A1 interacting protein 1 antibody; Inhibitor of CDK interacting with cyclin A1 antibody; MGC148150 antibody; MGC148151 antibody; Protein INCA1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Protein INCA1 protein (1-236AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，INCA1 Antibody (CSB-PA605764LA01HU)，的标记方式是Non-conjugated。对于INCA1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA605764LB01HU INCA1 Antibody, HRP conjugated ELISA
    FITC CSB-PA605764LC01HU INCA1 Antibody, FITC conjugated
    Biotin CSB-PA605764LD01HU INCA1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor. Inhibits cell growth and cell proliferation and may play a role in cell cycle control. Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth.
  • 基因功能参考文献：
    1. Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling PMID: 21540187
    2. Results indicate that ING5 is a growth suppressor with suppressed expression in AML whose functions depend on its interaction with INCA1. PMID: 21750715
  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    INCA family
  • 组织特异性：
    Detected in testis, and at lower levels in ovary. Detected at very low levels in testis tumors. Down-regulated in bone marrow cells in acute myeloid and lymphoid leukemia patients as compared with normal bone marrow cells.
  • 数据库链接：

    HGNC: 32224

    OMIM: 617374

    KEGG: hsa:388324

    STRING: 9606.ENSP00000380041

    UniGene: Hs.658926