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ID3 Antibody

  • 货号：
    CSB-PA576712
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA576712(ID3 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA576712(ID3 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q02535
  • 基因名：
  • 别名：
    1R21 antibody; bHLHb25 antibody; Class B basic helix-loop-helix protein 25 antibody; DNA binding protein inhibitor ID 3 antibody; DNA-binding protein inhibitor ID-3 antibody; HEIR 1 antibody; HEIR1 antibody; Helix loop helix protein HEIR 1 antibody; Helix loop helix protein HEIR1 antibody; Helix-loop-helix protein HEIR-1 antibody; HLH642 antibody; ID 3 antibody; ID like protein inhibitor HLH 1R21 antibody; ID like protein inhibitor HLH 462 antibody; ID-like protein inhibitor HLH 1R21 antibody; ID3 antibody; ID3_HUMAN antibody; Inhibitor of DNA binding 3 antibody; Inhibitor of DNA binding 3 dominant negative helix loop helix protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human ID3
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.
  • 基因功能参考文献：
    1. This review will discuss the current understanding of ID3 in excess fat accumulation and the potential for Estrogenic Endocrine Disruptors to influence susceptibility to obesity or metabolic disorders via ID3 signaling PMID: 29507860
    2. Taken together, we found that Id3+ and CTLA-4+ endometrial cells were significantly higher in women with repeated implantation failure and recurrent miscarriage, suggesting the negative roles of these angiogenesis and immune tolerance markers involving in regulating endometrium receptivity. PMID: 28224680
    3. The interactions between ID3 and the DNA damage mediator protein MDC1 suggest that ID3 participates in the DNA damage signaling pathway to maintain genomic stability. PMID: 29026069
    4. Immunohistochemical detection of inhibitor of DNA binding 3 mutational variants in mature aggressive B-cell lymphoma. PMID: 26992947
    5. The results of the present study revealed that overexpression of Id3 may serve as a novel strategy for inhibiting cisplatinsensitive lung cancer. PMID: 27176047
    6. Upon Id3 transfection, A549 cells displayed decreased migratory and invasive capabilities, however, co-transfection of miRId3 and Id3 into A549 cells reversed the Id3-induced inhibitions of migratory and invasive capabilities. PMID: 26384138
    7. ID3 has a role in the acquisition of molecular stem cell-like signature in microvascular endothelial cells PMID: 25665868
    8. our data provide evidence that ID3 may play a critical role in regulating vascular endothelial cell survival and development of microvascular lesions induced by persistent environmental pollutants such as PCB153. PMID: 25090023
    9. ID3 plays a potential role in the underlying regulatory mechanisms of metabolic health in human obesity. [Review] PMID: 25239768
    10. Epigenetic changes in ID3, in combination with experiences of maltreatment, may confer risk for depression in children. PMID: 24655651
    11. Data indicate association of inhibitor of differentiation 3 (ID3) single nucleotide polymorphism rs11574 directly with coronary artery pathology. PMID: 24603695
    12. Importantly, the distinct ID3 expression patterns in acute leukemias (AL) indicate a specific deregulation of ID3 in the various types of AL and may support subtyping of AL. PMID: 24292846
    13. the combined immunohistochemical detection of VPREB3 and ID3 is applicable to the routine diagnostic in case of mature aggressive B-cell lymphomas. PMID: 24493312
    14. ID3 mutations are recurrent events in double-hit B-cell lymphomas. PMID: 24222112
    15. High ID3 expression is associated with medulloblastoma seeding and is a poor prognostic factor, especially in patients with Group 4 tumors PMID: 23768125
    16. The findings suggested that cooperation between ID3 inactivation and immunoglobulin-MYC gene translocation is a hallmark of Burkitt lymphomagenesis. PMID: 23143595
    17. Overexpression of Id3 markedly promoted the proliferation and invasive capacity of MCF-7 cells; however, these effects were significantly suppressed by the overexpression of FHL2. PMID: 22882857
    18. Overexpression of Id3 triggered apoptosis in A549 lung adenocarcinoma cells, implicating Id3 in negative control of tumor growth. PMID: 22151756
    19. EGFR-AKT-Smad signaling promotes formation of glioma stem-like cells and tumor angiogenesis by ID3-driven cytokine induction. PMID: 21975932
    20. The ID3 protein is expressed in prostate cancer, and is elevated with the increase of Gleason score. PMID: 21837949
    21. the data establish dysregulation of the Id/bHLH axis as an early and sustained feature of ductal pathogenesis PMID: 21498546
    22. The level of Id-3 protein expression was associated with the malignant potential of gastric tumors. PMID: 20080245
    23. ID3 plays a role as an apoptosis inducer in response to X-ray irradiation via the regulation of endogenous beta-catenin level. PMID: 21030215
    24. In serum samples of lung cancer patients, galectin 1-mediated Id3 induces expression of interleukin (IL)-10 in functionally altered signal pathways of monocytes and monocyte-derived dendritic cells. PMID: 21191065
    25. Results provide novel evidence that Id3 is an atheroprotective factor and link a common SNP in the human ID3 gene to loss of Id3 function and increased carotid intima-media thickness. PMID: 20185798
    26. nuclear Id protein acts by sequestering pools of transiently diffusing bHLH protein to prevent reassociation with chromatin domains PMID: 12952978
    27. Fluvastatin did not regulate p21 and p27, but down-regulated Id3 and p53 slightly. PMID: 15370294
    28. Overexpression of Id3 enhances expression of ICAM-1 and E-selectin, and induces angiogenic processes such as transmigration, matrix metalloproteinase-2 and -9 expression, and tube formation in cultured vascular endothelial cells. PMID: 15494533
    29. ultraviolet radiation-induced apoptosis of immortalized keratinocytes is at least in part due to Id3 upregulation in these cells PMID: 16449966
    30. estrogen-induced tube formation in vascular endothelial cells requires the presence of Id3, a member of the helix-loop-helix family of transcriptional factors and estrogen increases Id3 phosphorylation via a redox-dependent process PMID: 18281048
    31. RhoA/Rho-associated kinase signaling plays positive and negative roles in myogenic differentiation, mediated by MRTF-A/Smad-dependent transcription of the Id3 gene in a differentiation stage-specific manner PMID: 18477564
    32. There is a mechanism whereby reactive oxygen species upregulation of Id3 relieves repression of bax via E-box-binding factors. PMID: 19054058
    33. RNA interference demonstrated that Id3 regulates differentiation and cell cycle (increased Neuro-D6 and p21 mRNA) in neuroblastoma cells PMID: 19477940

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain.
  • 数据库链接：

    HGNC: 5362

    OMIM: 600277

    KEGG: hsa:3399

    STRING: 9606.ENSP00000363689

    UniGene: Hs.76884