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HSD17B11 Antibody

  • 货号：
    CSB-PA843318HA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: HSD17B11 antibody at 10µg/ml + Mouse lung tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 33 kDa
      Observed band size: 33 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HSD17B11 Polyclonal antibody
  • Uniprot No.：
    Q8NBQ5
  • 基因名：
    HSD17B11
  • 别名：
    17 beta HSD 11 antibody; 17 beta HSD XI antibody; 17 BETA HSD11 antibody; 17 BETA HSDXI antibody; 17 beta hydroxysteroid dehydrogenase 11 antibody; 17 beta hydroxysteroid dehydrogenase type XI antibody; 17 beta hydroxysteroid dehydrogenase XI antibody; 17-beta-HSD 11 antibody; 17-beta-HSD XI antibody; 17-beta-hydroxysteroid dehydrogenase 11 antibody; 17-beta-hydroxysteroid dehydrogenase XI antibody; 17betaHSD11 antibody; 17betaHSDXI antibody; 17bHSD11 antibody; CTCL associated antigen HD CL 03 antibody; CTCL tumor antigen HD CL 03 antibody; CTCL-associated antigen HD-CL-03 antibody; Cutaneous T cell lymphoma associated antigen HD CL 03 antibody; Cutaneous T-cell lymphoma-associated antigen HD-CL-03 antibody; Dehydrogenase/reductase SDR family member 8 antibody; DHB11_HUMAN antibody; DHRS8 antibody; Estradiol 17 beta dehydrogenase 11 antibody; Estradiol 17-beta-dehydrogenase 11 antibody; Hsd17b11 antibody; Hydroxysteroid (17 beta) dehydrogenase 11 antibody; PAN1B antibody; Retinal short chain dehydrogenase/reductase 2 antibody; Retinal short-chain dehydrogenase/reductase 2 antibody; RETSDR2 antibody; SDR16C2 antibody; SDR2 antibody; Short chain dehydrogenase/reductase family 16C member 2 antibody; T cell lymphoma associated antigen HD CL 03 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Estradiol 17-beta-dehydrogenase 11 protein (20-300AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，HSD17B11 Antibody (CSB-PA843318HA01HU)，的标记方式是Non-conjugated。对于HSD17B11 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA843318HB01HU HSD17B11 Antibody, HRP conjugated ELISA
    FITC CSB-PA843318HC01HU HSD17B11 Antibody, FITC conjugated
    Biotin CSB-PA843318HD01HU HSD17B11 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.
  • 基因功能参考文献：
    1. knowledge of its in vitro activity together with a newly described expression pattern at the protein level in tissues involved in steroidogenesis and detoxification could suggest a potential role of DHRS8 in vivo PMID: 26472732
    2. hydroxysteroid (17-beta) dehydrogenase 11 transcription in prostate cancer cells is regulated by Sp1 transcription factor and C-EBP alpha PMID: 21549806
    3. Role for 17-beta-HSDXI in androgen metabolism during steroidogenesis. PMID: 12697717
    4. Mutation analyses suggest that the PAT-like motif in 17betaHSD11 will not be functionally similar to the canonical PAT motif. PMID: 18804447
    5. Increased Pan1b is associated with prostate cancer of seminal vesicle invasion. PMID: 19469652

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  • 亚细胞定位：
    Endoplasmic reticulum. Lipid droplet.
  • 蛋白家族：
    Short-chain dehydrogenases/reductases (SDR) family, 17-beta-HSD 3 subfamily
  • 组织特异性：
    Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of adult trachea, in
  • 数据库链接：

    HGNC: 22960

    OMIM: 612831

    KEGG: hsa:51170

    STRING: 9606.ENSP00000351035

    UniGene: Hs.594923