HOXD10 Antibody

1. Results show that HOXD10 promoter is hypermethylated in papillary thyroid cancer (PTC) tissues and its mRNA expression decreased. Moreover, the hypermethylation of HOXD10 was associated with invasion of the primary tumor. Further data provide evidence that the epigenetic suppression of the HOXD10 gene may play a role in the tumorigenesis of PTC. PMID: 29115628
2. Results show that HOXD10 is frequently methylated in human hepatocellular carcinoma (HCC), and the expression of HOXD10 is regulated by promoter region methylation. HOXD10 suppresses HCC cell growth both in vitro and in vivo. HOXD10 suppresses human HCC by inhibiting ERK signaling. PMID: 29075359
3. our data suggest that the loss of HoxD10 function is common and may thus result in a progressive phenotype in PCa. HoxD10 may function as a biomarker that differentiates patients with BCR disease from the ones that are not after radical prostatectomy, implicating its potential as a therapeutic target. PMID: 28231752
4. Knock down of the dickkopf WNT signaling pathway inhibitor 2 (DKK2) resulted in a significant suppression of HOXD10, HOXD11 and HOXD13 while over-expression of DKK2 and stimulation with factors of the WNT signaling pathway. PMID: 27363011
5. By treating LECs with VEGF-C156S and analyzing subsequent changes in gene expression, we identified several 'immediate early' transcription factors that showed a rapid transient upregulation VEGFR-3 stimulation. these results reveal an important and unanticipated role of HOXD10 in the regulation of VEGFR-3 signaling in lymphatic endothelial cells, and in the control of lymphangiogenesis and permeability. PMID: 27199372
6. Knockdown of HOXD10 in renal cells also resulted in increased resistance to colistin cytotoxicity. PMID: 28335481
7. High expression of HOXD10 is associated with laryngeal squamous cell carcinoma. PMID: 27658780
8. Low HOXD10 promotes migration and invasion in gastric cancer. PMID: 26311318
9. These results suggested that HOXD10 may be a putative suppressor gene and can act as a prognostic marker and potentially a novel therapeutic target for cholangiocellular carcinoma. PMID: 26260613
10. miR-23a was upregulated in glioma. This overexpression promoted glioma cell invasion, probably by modulating MMP-14 via directly inhibiting the expression of HOXD10. PMID: 24305689
11. POU2F1 activity regulates HOXD10 and HOXD11 gene expression in head and neck squamous cell carcinoma, promoting a proliferative and invasive phenotype. PMID: 25301728
12. Downregulation of the HOXD10 gene expression was associated with breast cancer. PMID: 25081374
13. KLF4 and HOXD10 were identified as direct targets of miR-10b in bladder cancer cells PMID: 24573354
14. It is a member of the HOX gene family. HOX genes are the main regulatory genes that directly influence organogenesis and maintain the function of differentiated tissues PMID: 24219032
15. MicroRNA-10b promotes nucleus pulposus cell proliferation through RhoC-Akt pathway by targeting HOXD10 in intervetebral disc degeneration. PMID: 24376640
16. HOXD10 expression varies by stage of disease and produces differential effects in head and neck squamous cell carcinoma. PMID: 25010866
17. TBX1 can alter TGF-beta/BMP, an important signaling pathway, through interacting with HOXD10. Above findings may shed light on the mechanism of TBX1 mutations leading to renal malformations found in patients carrying a 22q11 deletion. PMID: 22842189
18. downregulation of HOXD10 expression by miR-10b overexpression may induce an increase of pro-metastatic gene products, such as MMP14 and RHOC, and contribute to the acquisition of metastatic phenotypes in epithelial ovarian cancer cells PMID: 23670532
19. HoxD10 potentially functions as a tumor suppressor that is inactivated through promoter hypermethylation in gastric cancer. PMID: 22160393
20. Suggest that miR-10b can stimulate the upregulation of RhoC and AKT phosphorylation through targeting HOXD10, thus promoting cell invasion in gastric tumors. PMID: 22293682
21. miR-10b induced glioma cell invasion by modulating tumor invasion factors MMP-14 and uPAR expression via the direct target HOXD10 PMID: 21419107
22. results indicate a role for HoxD10 in maintaining a nonangiogenic state in the endothelium PMID: 12466126
23. Missense Mutation in HOXD10 is associated with congenital vertical talus and Charcot-Marie-Tooth disease PMID: 15146389
24. An autosomal-dominant-inherited mutation in a HOXD10 gene with complete penetrance is found in all members of a pedigree with congenital vertical talus. PMID: 15368082
25. No evidence was found of linkage near the HOXD gene cluster on chromosome 2q, suggesting genes other than HOXD10 are responsible for idiopathic clubfoot. PMID: 17417092
26. Pak1 is a target of miR-7 and that HoxD10 plays a regulatory role in modifying the expression of miR-7. PMID: 18922890

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HGNC: 5133

OMIM: 142984

KEGG: hsa:3236

STRING: 9606.ENSP00000249501

UniGene: Hs.123070