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HOMER3 Antibody

  • 中文名称：
    HOMER3兔多克隆抗体
  • 货号：
    CSB-PA878880LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse brain tissue
      All lanes: HOMER3 antibody at 2.7μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 40, 17, 14, 36 kDa
      Observed band size: 40 kDa
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA878880LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HOMER3 Polyclonal antibody
  • Uniprot No.：
    Q9NSC5
  • 基因名：
  • 别名：
    HOME3_HUMAN antibody; HOMER 3 antibody; Homer 3D protein antibody; Homer homolog 3 (Drosophila) antibody; Homer neuronal immediate early gene 3 antibody; Homer protein homolog 3 antibody; Homer-3 antibody; Homer3 antibody; VESL3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Homer protein homolog 3 protein (151-361AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，HOMER3 Antibody (CSB-PA878880LA01HU)，的标记方式是Non-conjugated。对于HOMER3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA878880LB01HU HOMER3 Antibody, HRP conjugated ELISA
    FITC CSB-PA878880LC01HU HOMER3 Antibody, FITC conjugated
    Biotin CSB-PA878880LD01HU HOMER3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.
  • 基因功能参考文献：
    1. Homer3 acts as a scaffold that spatially organizes actin assembly to support neutrophil polarity and motility downstream of GPCR activation. PMID: 25739453
    2. Interaction of the protein with amyloid precursor protein is regulated by calcium homeostasis. PMID: 24792907
    3. Loss of Homer3 is associated with acute myeloid leukemia. PMID: 23725168
    4. Homer3 specifically associates with a novel ubiquitin-like domain in the I kappa B kinase (IKK) beta subunit of the IKK complex. PMID: 20693425
    5. Homer-3 may be involved in the regulation of SRE activation in T cells via interaction between its EVH1 domain and C/EBP beta. PMID: 14645007
    6. Fat1 exhibit co-localisation with Homer-3 in cellular protrusions and at the plasma membrane of HeLa cells PMID: 16979624
    7. study found that Homer2 and Homer3 are negative regulators of T cell activation; this is achieved through binding of nuclear factor of activated T cells (NFAT) and by competing with calcineurin PMID: 18218901

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  • 亚细胞定位：
    Cytoplasm. Cell junction, synapse, postsynaptic density. Cell junction, synapse.
  • 蛋白家族：
    Homer family
  • 数据库链接：

    HGNC: 17514

    OMIM: 604800

    KEGG: hsa:9454

    STRING: 9606.ENSP00000376162

    UniGene: Hs.720208