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HDAC10 Antibody

  • 货号：
    CSB-PA002914
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COS7 cells using Histone deacetylase 10 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q969S8
  • 基因名：
    HDAC10
  • 别名：
    DKFZP761B039 antibody; HD 10 antibody; HD10 antibody; HDA10_HUMAN antibody; HDAC 10 antibody; Hdac10 antibody; Histone deacetylase 10 antibody; MGC149722 antibody; OTTHUMP00000028555 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat,Monkey
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human Histone deacetylase 10.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine. Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine. Histone deacetylase activity has been observed in vitro. Has also been shown to be involved in MSH2 deacetylation. The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak. May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells. May play a role in homologous recombination. May promote DNA mismatch repair.
  • 基因功能参考文献：
    1. HDAC10 structure and molecular function as a polyamine deacetylase has been reported. PMID: 28516954
    2. this study demonstrated that HDAC10 localizes and functions in the cytoplasm of lung cancer cells, thereby underscoring its potential role in the diagnosis and treatment of lung cancer PMID: 27449083
    3. HDAC10 regulates cyclin A2 expression by deacetylating histones near the let-7 promoter. PMID: 26240284
    4. study identifies an HDAC10-mediated regulatory mechanism controlling the DNA mismatch repair function of MSH2. PMID: 26221039
    5. Suggest HDAC10 expression as a prognostic marker for gastric cancer. PMID: 25337229
    6. this study is describing HDAC10 as a promoter of autophagy-mediated survival in neuroblastoma cells and identifying this HDAC isozyme as a druggable regulator of advanced-stage tumor cell survival. PMID: 24145760
    7. HDAC10 suppresses expression of matrix metalloproteinase (MMP) 2 and 9 genes, which are known to be critical for cancer cell invasion and metastasis PMID: 23897811
    8. results demonstrate that HDAC10 protects cancer cells from cytotoxic agents by mediating autophagy and identify this HDAC isozyme as a druggable regulator of advanced-stage tumor cell survival PMID: 23801752
    9. Histone deacetylases 9 and 10 are required for homologous recombination. PMID: 21247901
    10. HDAC10 is involved in transcriptional downregulation of TXNIP, leading to altered reactive oxygen species signaling in human gastric cancer cells. PMID: 20680488
    11. Results not only show that HDAC10 regulates melanogenesis but also demonstrate that the transcriptional activities of Pax3 and KAP1 are intimately linked to their acetylation status. PMID: 20032463
    12. another histone deacetylase PMID: 11739383
    13. molecular cloning and characterization of a novel class II histone deacetylase PMID: 11861901
    14. Reduced expression of histone deacetylase 10 is associated lung cancer PMID: 15305372
    15. Results suggest that the "T" allele of HDAC10-589C>T affect on the increased transcription activity, and might accelerate HCC development through increased expression of HDAC10. PMID: 17892858

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Histone deacetylase family, HD type 2 subfamily
  • 组织特异性：
    Widely expressed with high levels in liver and kidney.
  • 数据库链接：

    HGNC: 18128

    OMIM: 608544

    KEGG: hsa:83933

    STRING: 9606.ENSP00000216271

    UniGene: Hs.26593