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  4. GTSE1 Antibody

GTSE1 Antibody

  • 货号：
    CSB-PA010041GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NYZ3
  • 基因名：
  • 别名：
    GTSE1 antibody; G2 and S phase-expressed protein 1 antibody; GTSE-1 antibody; Protein B99 homolog antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human GTSE1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression.
  • 基因功能参考文献：
    1. G2 and S-phase expressed 1 (GTSE1) expression promotes AM progression and correlates with clinical outcomes of patients with acral melanoma (AM), and may represent a promising therapeutic target to suppress AM progression. PMID: 29660787
    2. GTSE1 is expressed exclusively in late G2 and M phase. From nuclear envelope breakdown until anaphase onset, GTSE1 binds preferentially to the most stable mitotic spindle microtubules and promotes their turnover. PMID: 28821562
    3. Results indicated for the first time that overexpression of GTSE1 was involved in the progress of HCC, enhancing proliferation and promoting cell invasion in HCC cells. PMID: 27240802
    4. Study identifies GTSE1 as a biomarker for cisplatin resistance in gastric cancer cells and suggests its repressive role in cisplatin induced apoptosis making it a potential therapeutic target for better clinical management of gastric cancer patients. PMID: 26209226
    5. GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration. PMID: 23236459
    6. GTSE1 is overexpressed dramatically in lung cancer patients' tissues. PMID: 22292647
    7. Data show that G2 and S-phase-expressed 1 (GTSE1) protein, a negative regulator of p53, is required for G2 checkpoint recovery and that Plk1 phosphorylation of GTSE1 promotes its nuclear localization. PMID: 20577264
    8. hGTSE-1 mediated-p21(CIP1/WAF1) stabilization is clearly involved in the ability of cells to counteract cytotoxicity induced by the microtubule poison paclitaxel. PMID: 20018861
    9. GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function PMID: 12750368
    10. requires an intact nuclear export signal and functional Mdm2 for the regulation of p53 PMID: 14707141

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Note=Associated with microtubules.
  • 数据库链接：

    HGNC: 13698

    OMIM: 607477

    KEGG: hsa:51512

    STRING: 9606.ENSP00000415430

    UniGene: Hs.386189