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GSTZ1 Antibody

  • 货号：
    CSB-PA009994DSR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA009994DSR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GSTZ1 Polyclonal antibody
  • Uniprot No.：
    O43708
  • 基因名：
    GSTZ1
  • 别名：
    EC 2.5.1.18 antibody; EC 5.2.1.2 antibody; Glutathione S transferase zeta 1 antibody; Glutathione S-transferase zeta 1 antibody; Gstz1 antibody; GSTZ1-1 antibody; MAAI antibody; MAAI_HUMAN antibody; Maleylacetoacetate isomerase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Maleylacetoacetate isomerase protein (1-216AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid.
  • 基因功能参考文献：
    1. Some properties of cytosolic and mitochondrial GSTZ1 differed. PMID: 29853471
    2. mild hypersuccinylacetonaemia (MHSA)can be caused by sequence variants in GSTZ1. Such individuals have thus far remained asymptomatic despite receiving no specific treatment. PMID: 27876694
    3. rs7975 GG carriers had an increased risk of below-reference sperm motility PMID: 26970898
    4. We conclude that the lower expression of GSTZ1 in Whites who possess the K carrier haplotype results in lower enzymatic activity and slower metabolism of DCA, compared with those who possess the non-K carrier haplotype PMID: 25738370
    5. Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in children PMID: 25079374
    6. The data indicates no association between GSTZ1 genotypes and risk of gastric cancer. PMID: 24719983
    7. Two SNPs, rs282070 located in intron 1 of the MAP3K7 gene, and rs2111699 located in intron 1 of the GSTZ1 gene, were significantly associated (after adjustment for multiple testing) with longevity in stage 2 PMID: 22576335
    8. The ping-pong catalytic mechanism of Se-hGSTZ1-1 is similar to that of the natural GPX. PMID: 23280616
    9. Elucidation of the role of individual residues in the N-terminal, SSC motif of human GSTZ1. PMID: 23299908
    10. This study was performed on 228 BPD patients and 234 control subjects. Among early-onset patients, the variant alleles of Glu32Lys and G-1002A increased BPD susceptibility. PMID: 22374552
    11. e report for the first time the conversion of human glutathione transferase Zeta (hGSTZ1-1) into seleno-hGSTZ1-1 by means of genetic engineering in eukaryotes. PMID: 22561244
    12. The present results indicate that the haplotype of "-1002A, 32Lys, 42Arg" (containing three variant alleles) of GSTZ1 have protective effect compared to the other haplotypes. PMID: 22729907
    13. Our study did not support any association between susceptibility to exudative AMD (age-related macular degeneration) and polymorphisms of GSTZ1. PMID: 21948024
    14. Data suggest neonatal onset and age-related increase in GSTZ1 protein expression during liver development/growth. GSTZ1 haplotype influences activity with dichloroacetate but not protein expression. PMID: 22028318
    15. polymorphisms of GSTZ1 showed strong linkage disequilibrium among cancer patients and control su PMID: 21823988
    16. Results describe the genotypic frequencies of glutathione S-transferase Z1 polymorphisms among an Iranian population. PMID: 21107728
    17. The results of this study did not support the association between genetic polymorphisms of glutathione S-transferase Z1 (GSTZ1) and susceptibility to schizophrenia. PMID: 21183226
    18. subjects with polymorphisms in GSTZ1 have a higher trihalomethanes induced bladder cancer susceptibility PMID: 20675267
    19. A new allele of GSTZ1 (maleylacetoacetate isomerase), characterized by a Thr82Met substitution and termed GSTZ1d, has been identified by analysis of the expressed sequence tag (EST) database. PMID: 11692075
    20. Single nucleotide polymorphisms may alter GSTZ1 expression, which may alter the pharmacokinetics of DCA, which is used therapeutically for the treatment of lactic acidosis. PMID: 16609361
    21. Kinetic studies revealed that the catalytic mechanism of Se-hGSTZ1-1 belong in a ping-pong mechanism similar to that of the natural glutathione peroxidase. PMID: 18373941
    22. The results are consistent with the hypothesis that reduced dopamine metabolism adversely affects cognition. PMID: 18628685

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  • 相关疾病：
    Maleylacetoacetate isomerase deficiency (MAAID)
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    GST superfamily, Zeta family
  • 组织特异性：
    Mostly expressed in liver followed by kidney, skeletal muscle and brain. Also expressed in melanocytes, synovium, placenta, breast and fetal liver and heart.
  • 数据库链接：

    HGNC: 4643

    OMIM: 603758

    KEGG: hsa:2954

    STRING: 9606.ENSP00000216465

    UniGene: Hs.655292