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GPR64 Antibody

  • 货号：
    CSB-PA912224
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA912224(GPR64 Antibody) at dilution 1/55, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q8IZP9
  • 基因名：
  • 别名：
    ADGRG2 antibody; GPR64 antibody; HE6 antibody; TM7LN2Adhesion G-protein coupled receptor G2 antibody; G-protein coupled receptor 64 antibody; Human epididymis-specific protein 6 antibody; He6 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human GPR64
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis.
  • 基因功能参考文献：
    1. identified two missense variants in two congenital bilateral absence of the vas deferens (CBAVD) patients (c.G1709A, p.C570Y; and c.A2968G, p.K990E); study did not find any potential pathogenic CFTR variants, implying the ADGRG2 variants are the genetic cause in these patients PMID: 28805948
    2. GPR64 is expressed on the cell surface of parathyroid cells, is overexpressed in parathyroid tumors, and physically interacts with the CaSR. PMID: 27760455
    3. study confirms the crucial role of ADGRG2 in human male fertility and brings new insight into congenital obstructive azoospermia pathogenesis; in men with CBAVD who are CFTR-negative, ADGRG2 testing could allow for appropriate genetic counseling with regard to the X-linked transmission of the molecular defect PMID: 27476656
    4. Knockdown of ADGRG2 breast cancer cell lines resulted in a strong reduction in cell adhesion and subsequent cell migration which was associated with a selective reduction in RelB. PMID: 26321231
  • 相关疾病：
    Congenital bilateral aplasia of the vas deferens, X-linked (CBAVDX)
  • 亚细胞定位：
    Apical cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily
  • 组织特异性：
    Epididymis-specific expression (at protein level). Both subunits are associated with apical membranes of efferent ductule and proximal epididymal duct epithelia. Mainly expressed in the nonciliated principal cells of the proximal excurrent ducts. Specific
  • 数据库链接：

    HGNC: 4516

    OMIM: 300572

    KEGG: hsa:10149

    STRING: 9606.ENSP00000369198

    UniGene: Hs.146978