GPER1 Antibody

1. serum levels of GPER, but not estrogen, are significantly decreased in ADHD patients compared to controls PMID: 29659348
2. The findings indicate that GPER/miR148a/HLAG signaling pathway may mediates the development of ovarian endometriosis and may become a potential therapeutic target for the treatment of endometriosis. PMID: 29845209
3. Nuclear GPR30 is overexpressed and predicts poor survival in patients with ovarian cancer. PMID: 29239277
4. These findings shed new light on the essential role played by GPER in IGF1/IGF1R signaling that induces breast tumor angiogenesis. PMID: 29212519
5. The significant and consistent increase in GPER expression in adenomyosis compared with control subjects, regardless of whether it was in the proliferative or secretory phases and regardless of whether it was in the JZ or OM, suggests that GPER plays an important role in the pathogenesis of the adenomyosis PMID: 29109960
6. Levels of GPR30 were significantly reduced in placentae from women with preeclampsia as compared with uncomplicated pregnancies. PMID: 28849224
7. High expression of GPER is associated with triple-negative breast cancer. PMID: 28535016
8. Serum GPR30 levels were significantly lower in autism spectrum disorders patients than in controls. PMID: 28734238
9. GPER P16L is defective for membrane-associated signaling, but instead acts like an estrogen-stimulated transcription factor. In CAFs, it induces the secretion of paracrine factors that promote the migration of carcinoma cells. This raises the possibility that the GPER P16L polymorphism could be a risk factor for breast cancer. PMID: 28596490
10. These data thus demonstrate that estrogen prevents the failure of endothelial cell tube formation induced byhypoxia/reoxygenation. GPR30 plays an important role in these protective effects through the activation of eNOS and Akt in endothelial cells. PMID: 28440394
11. Epigenetic down regulation of GPER acts as a tumor suppressor in colorectal cancer and its specific activation might be a potential approach for colorectal cancer treatment. PMID: 28476123
12. Data suggest that IGF-I/IGF-IR system triggers stimulatory actions through both GPER and DDR1 in aggressive tumors as mesothelioma and lung tumors. PMID: 27384677
13. The G protein-coupled estrogen receptor agonist G-1 inhibits nuclear estrogen receptor activity and stimulates novel phosphoproteomic signatures in MCF-7 cells. PMID: 27026707
14. Utilizing both genetic and pharmacologic approaches, the s establish that sex steroid effects on human melanin synthesis are mediated by the membrane-bound, steroid hormone receptors G protein-coupled estrogen receptor (GPER), and progestin and adipoQ receptor 7 (PAQR7). PMID: 27115344
15. This study demonstrated that GPER1 levels were associated with the anxiety levels of patients, and that the serum GPER1 level was a valuable predictor of the presence of anxiety independent of gender. PMID: 27512921
16. These clinical data showed that the expression of G-protein coupled estrogen receptor (GPER) is negatively associated with lymph node metastasis, high-grade tumor and fibronectin (FN) expression while positively associated with the favorable outcome in 135 triple negative breast cancer cells patients. PMID: 26842883
17. Either by specific inhibitors for GPER, ERK, AKT and NF-kappaB, or by knock-down of GPER. PMID: 27940299
18. The intron variant rs4265085 of GPER1 may confer risk for recurrent spontaneous abortion in Dai and Bai ethnic groups in China. PMID: 28126236
19. Activation of GPER can suppress migration and angiogenesis of triple negative breast cancer by inhibiting of NF-kappaB/IL-6 signaling. PMID: 27836733
20. GPER protects against hepatic tumorigenesis by regulating inflammatory responses. PMID: 27594673
21. GPER enhances melanogenesis via PKA by upregulating microphthalmia-related transcription factor-tyrosinase in melanoma PMID: 27378491
22. Data suggest that GPR30 increases ERK1/2 activity via two Gi/o-mediated mechanisms, a PDZ-dependent constitutive mechanism and a PDZ-independent Gi/o-stimulated mechanism involving PI3K. (GPR30 = G protein-coupled estrogen receptor 1; ERK1 = extracellular signal-regulated kinase 1; ERK2 = extracellular signal-regulated kinase 2; Gi/0 = GTP-binding protein alpha subunits, Gi-Go; PI3K = phosphoinositide-3-kinase) PMID: 28450397
23. present study revealed that BPA can trigger the progression of laryngeal squamous cell carcinoma via GPER-mediated upregulation of IL-6. Therefore, more attention should be paid for the BPA exposure on the development of laryngeal cancer. PMID: 28466560
24. G protein-coupled estrogen receptor stabilizes HIF-1alpha and thus promotes HIF-1alpha-induced VEGF and MMP9 in endometrial stromal cells, which play critical roles in endometriosis. PMID: 27939762
25. GPR30 activation by G-1 interfered expression of cell cycle regulators and machinery elements to modulate prostate cancer cell growth PMID: 27908592
26. These results provide evidence that (1) GPR30 is involved in regulating cell proliferation and apoptosis; (2) pharmacologic upregulation of GPR30 is beneficial for preeclampsia (PE) management; (3) GPR30 may therefore be an interventional target for pregnancies complicated by PE. PMID: 27481507
27. Thus, the presence or absence of these GPR30 species is a simple and rapid manner to determine whether a given cell line is suitable for pharmacological or molecular studies of GPR30 modulation. PMID: 27401115
28. Data define novel insights into the stromal GPER-mediated multiple drug resistance from the point of reprogramming of tumor energy metabolism and provide the rationale for CAFs as a promising target for clinical therapy. PMID: 27721408
29. GPER may play a role during human oocyte maturation through its action in cumulus granulosa cells PMID: 27111051
30. ligand-activation of GPER generates a feedforward loop coupling IL1beta induction by CAFs to IL1R1 expression by cancer cells, promoting the up-regulation of IL1beta/IL1R1 target genes such as PTGES, COX2, RAGE and ABCG2 PMID: 27072893
31. Studies identified an important role of GPER activation in the regulation of cardiovascular function especially in women. [review] PMID: 27213340
32. GPER negatively regulates TNFalpha-induced IL-6 expression, probably through inhibition of NF-kappaB promoter activity by a signal(s) derived from the C-terminal region of GPER. PMID: 26888479
33. Results demonstrated that GPER protein down-regulation significantly correlated with GPER promoter hypermethylation. Comparison of 108 tumors and matched normal breast tissues indicated a significant GPER down-regulation in cancer tissues correlating with GPER promoter hypermethylation. PMID: 28118074
34. Data suggest that expression of GPER1/GPR30 can be up-regulated by dietary factors; dietary supplementation with flaxseed-derived lignan, secoisolariciresinol diglycoside, up-regulates expression of GPER1/GPR30 in prostate and may prevent progression of benign prostatic hyperplasia. PMID: 27849354
35. the presence of the GG genotype of the GPR30 rs3808351 polymorphism and the G allele of the GPR30 rs3808351 polymorphism affect the characteristics and development of leiomyomas in the Turkish population PMID: 26773178
36. GPER expression was mainly con fi ned in the basal epithelial layer of benign prostate, where this receptor could mediate estrogen action on normal cellular activity. PMID: 26714890
37. Data show that both mineralcorticoid receptor (MR) and G-protein estrogen receptor (GPER) contribute to the proliferation and migration of breast and endothelial cancer cells by sodium-hydrogen exchanger 1 protein (NHE-1) upon aldosterone exposure. PMID: 26646587
38. GPER ligand-independently stimulates the proliferation, migration and invasion of SKOV3 cells. PMID: 26526233
39. Study provides perspective that addresses the accumulation of GPER in endosomes or intracellular membranes, its capacity to transactivate plasma membrane receptors and its potential role in physiological and pathophysiological processes. [review] PMID: 26190834
40. Evaluation of GPER1, EGFR and CXCR1 mRNA/protein expression may be helpful in differential diagnosis of malignant follicular thyroid carcinoma and benign follicular thyroid adenoma. PMID: 26617848
41. Results indicate that GPER-1 mediates proliferation of estrogen-induced leiomyoma cells by activating the MAPK pathway, and not by promoting mitosis. PMID: 26416628
42. GPER significantly attenuated the inhibition effect of miR-424 in estradiol-induced cell growth in the endometrial cancer cells. PMID: 26638889
43. The G protein-coupled estrogen receptor 1 (GPER-1) contributes to the proliferation and survival of mantle cell lymphoma cells. PMID: 26250574
44. Understanding the molecular basis of agonist/antagonist mechanism of GPER1/GPR30 through structural and energetic analyses PMID: 26772481
45. Expression and functional roles of estrogen receptor GPR30 in human intervertebral disc PMID: 26815911
46. Data show that estrogen mediates control of hepatitis C virus through the G-protein-coupled estrogen receptor 30 (GPR30) pathway leading to cleavage of occludin by Matrix Metalloproteinase-9 (MMP-9). PMID: 26731262
47. a significant positive correlation was found between GPER and Gankyrin both in ectopic and eutopic endometrium of the ovarian endometriosis. PMID: 26193952
48. In estradiol-treated monocytes, GPER1 physically interacts with estrogen receptor-alpha 36-kDa splice variant. It acts an anti-inflammatory coregulator, because its inhibition blocks estrogen's effect on IL-6 expression. PMID: 26394816
49. Study highlighted the physiological function of GPER1, particularly its regulation of AT1R and the role of estrogen receptors, EGFR and matrix metalloproteinases in bringing about its cardioprotective effects. [review] PMID: 25922871
50. GPER undergoes dramatic structural changes, which explains its exceptional capacity to accept diverse agonist and antagonist ligands. PMID: 25587872

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HGNC: 4485

OMIM: 601805

KEGG: hsa:2852

STRING: 9606.ENSP00000297469

UniGene: Hs.20961