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GNB2 Antibody

  • 货号：
    CSB-PA009604GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P62879
  • 基因名：
  • 别名：
    G protein beta 2 subunit antibody; G protein subunit beta 2 antibody; G protein subunit beta-2 antibody; GBB2_HUMAN antibody; Gnb2 antibody; Gnb2l1 antibody; Guanine nucleotide binding protein beta 2 subunit antibody; Guanine nucleotide binding protein G I G S G T beta 2 subunit 2 antibody; Guanine nucleotide binding protein G protein beta polypeptide 2 antibody; Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 antibody; OTTHUMP00000174601 antibody; OTTHUMP00000174602 antibody; RACK1 antibody; Receptor for activated C kinase antibody; Receptor of activated protein kinase C 1 antibody; Signal transducing guanine nucleotide binding regulatory protein beta antibody; Transducin beta chain 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human GNB2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
  • 基因功能参考文献：
    1. A GNB2 gene mutation is associated with familial sinus node and atrioventricular conduction dysfunction. PMID: 28219978
    2. MIF and GNbeta2 interacted with influenza A H1N1 virus PB1-F2 protein. PMID: 23043599
    3. Results indicate that G protein beta2 (Gbeta2) is required for starvation-induced NF-kappaB activation and constitutive NF-kappaB activity. PMID: 22917497
    4. We conclude that the Gbetagamma complex interacts with the GR and suppresses its transcriptional activity by associating with the transcriptional complex formed on GR-responsive promoters. PMID: 15955845
    5. Recombinant Gbetagamma subunits were used to establish that the Gbeta(2)gamma(2) dimer can selectively reconstitute the inhibition of alpha(1H) channels in isolated membrane patches. PMID: 16973746

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  • 亚细胞定位：
    Cytoplasm, perinuclear region.
  • 蛋白家族：
    WD repeat G protein beta family
  • 数据库链接：

    HGNC: 4398

    OMIM: 139390

    KEGG: hsa:2783

    STRING: 9606.ENSP00000305260

    UniGene: Hs.185172