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GNA14 Antibody

  • 货号：
    CSB-PA009586LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: GNA14 antibody at 3µg/ml + Mouse lung tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 42 kDa
      Observed band size: 42 kDa
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA009586LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品描述：

    CUSABIO immunizes the rabbit with a peptide mapping within amino acids 8-303 of the human GNA14 protein thus obtaining the anti-GNA14 antibody. This polyclonal antibody against GNA14 is an unconjugated IgG. It can react with human and mouse samples. Its target protein GNA14 is involved in the regulation of hypertension and endothelial function. And GNA14 silencing inhibits endometrial carcinoma cell proliferation. The purity of this antibody is greater than 95% using protein G purified. This GNA14 antibody is suitable for use in ELISA, WB, and IHC applications.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GNA14 Polyclonal antibody
  • Uniprot No.：
    O95837
  • 基因名：
  • 别名：
    AU023208 antibody; g alpha 14 antibody; G alpha-14 antibody; G protein alpha subunit 14 antibody; G protein subunit alpha 14 antibody; G-protein subunit alpha-14 antibody; gna14 antibody; GNA14_HUMAN antibody; Guanine nucleotide binding protein (G protein) alpha 14 antibody; Guanine nucleotide binding protein 14 antibody; Guanine nucleotide binding protein alpha 14 subunit antibody; Guanine nucleotide binding protein subunit alpha 14 antibody; Guanine nucleotide-binding protein subunit alpha-14 antibody; MGC105546 antibody; OTTHUMP00000021515 antibody; Tieg3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Guanine nucleotide-binding protein subunit alpha-14 protein (8-303AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，GNA14 Antibody (CSB-PA009586LA01HU)，的标记方式是Non-conjugated。对于GNA14 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA009586LB01HU GNA14 Antibody, HRP conjugated ELISA
    FITC CSB-PA009586LC01HU GNA14 Antibody, FITC conjugated
    Biotin CSB-PA009586LD01HU GNA14 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
  • 基因功能参考文献：
    1. The findings of the work indicate a role for Galphaq and/or Galpha14 and in CCR2a/CCR2b-stimulated Rho A GTPase-mediated serum response factor activation. PMID: 26823487
    2. findings identify GNA14 mutations as a cause of childhood vascular tumors, offer insight into mechanisms of oncogenic transformation by mutations affecting Gaq family members, and identify potential targets for therapeutic intervention PMID: 27476652
    3. Study suggests that the previously identified PLCbeta-interacting residues are insufficient to ensure productive interaction of Galpha14 with PLCbeta, while an intact N-terminal half of Galpha14 is apparently required for PLCbeta interaction. PMID: 26377666
    4. TNF-alpha/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells. PMID: 23975421
    5. TPR1 is required for Galpha14 to stimulate Ras-dependent signaling pathways, but not for the propagation of signals along Ras-independent pathways. PMID: 22711498
    6. activation of the IKK/NFkappaB signaling cascade by SSTR2 requires a complicated network consisting of Galpha(14), protein kinase C, CamkII, ERK, and c-Src PMID: 16115892
    7. G14alpha and G16alpha are palmitoylated at distinct polycysteine sequences, and that the adjacent polybasic domain is not required for Galpha palmitoylation but is important for localization and functional activity of heterotrimeric G proteins PMID: 17620339
    8. The ability of CCR1 to signal through Galpha(14/16) thus provides a linkage for chemokines to regulate NF-kappaB-dependent responses. PMID: 19687291

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  • 蛋白家族：
    G-alpha family, G(q) subfamily
  • 数据库链接：

    HGNC: 4382

    OMIM: 604397

    KEGG: hsa:9630

    STRING: 9606.ENSP00000365807

    UniGene: Hs.657795