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GIT2 Antibody

  • 货号：
    CSB-PA613489LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA613489LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA613489LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GIT2 Polyclonal antibody
  • Uniprot No.：
    Q14161
  • 基因名：
  • 别名：
    ARF GAP GIT2 antibody; ARF GTPase activating protein GIT2 antibody; ARF GTPase-activating protein GIT2 antibody; CAT 2 antibody; CAT-2 antibody; CAT2 antibody; Cool associated tyrosine phosphorylated protein 2 antibody; Cool interacting tyrosine phosphorylated protein 2 antibody; Cool-interacting tyrosine-phosphorylated protein 2 antibody; DKFZp686G01261 antibody; G protein coupled receptor kinase interacting ArfGAP 2 antibody; G protein coupled receptor kinase interactor 2 antibody; G protein-coupled receptor kinase-interactor 2 antibody; GIT 2 antibody; GIT2 antibody; GIT2_HUMAN antibody; GRK interacting protein 2 antibody; GRK-interacting protein 2 antibody; KIAA0148 antibody; MGC760 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human ARF GTPase-activating protein GIT2 protein (1-603AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，GIT2 Antibody (CSB-PA613489LA01HU)，的标记方式是Non-conjugated。对于GIT2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA613489LB01HU GIT2 Antibody, HRP conjugated ELISA
    FITC CSB-PA613489LC01HU GIT2 Antibody, FITC conjugated
    Biotin CSB-PA613489LD01HU GIT2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    GTPase-activating protein for ADP ribosylation factor family members, including ARF1.
  • 基因功能参考文献：
    1. our work identifies DOCK5 as a key regulator of epithelial invasion and metastasis, and demonstrates that suppression of DOCK5 by GIT2 represents a previously unappreciated mechanism for coordination of Rho and Rac GTPases. PMID: 27669437
    2. Short-term EGF stimulation if of lung tumor cells can increase the interaction between RUSC2 and GIT2, prolonged stimulation leads to a decrease of their interaction through activating Rab35. PMID: 27238570
    3. GIT2 plays an important role in MRE11/ATM/H2AX-mediated DNA damage responses. PMID: 25605334
    4. ADMA and L-arginine are substrates of human CAT2A, CAT2B, OCT2 and MATE1. Transport kinetics of CAT2A, CAT2B, and OCT2 indicate a low affinity, high capacity transport, which may be relevant for renal and hepatic elimination of ADMA or L-arginine PMID: 23864433
    5. Zeb1 is regulated by the Arf GTPase-activating protein (GAP) Git2. PMID: 23591815
    6. GIT2 protein is tightly associated with PIX family Rac1/Cdc42 guanine nucleotide exchange factors as a multimeric nexus capable of linking together important signaling molecules. PMID: 15212761
    7. The expression level of lymphocyte GRK might show the severity of CHF, and ACEI treatment could reduce the level of GRK in CHF patients. PMID: 16501306
    8. GTI proteins regulate cytoskeletal dynamics by feedback inhibition of Rac1, they participate in receptor internalization by regulating membrane trafficking between PMID: 16598076
    9. These results suggest that inactivation of GIT2 function is a required step for induction of cell motility and that GIT2 may be a target of oncogenic signaling pathways that regulate cell migration. PMID: 16628223
    10. Git2-short, weakly interacting with paxillin, functions in the regulation of Golgi organization, actin cytoskeletal organization, and subcellular localization of paxillin, important in integrin-mediated cell adhesion and intracellular signaling. PMID: 11251077

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  • 数据库链接：

    HGNC: 4273

    OMIM: 608564

    KEGG: hsa:9815

    STRING: 9606.ENSP00000347464

    UniGene: Hs.434996