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FTSJ1 Antibody

  • 货号：
    CSB-PA009055LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: FTSJ1 antibody at 2µg/ml
      Lane 1: HepG2 whole cell lysate
      Lane 2: Mouse brain tissue
      Lane 3: EC109 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/15000 dilution
      Predicted band size: 37, 36 kDa
      Observed band size: 37 kDa
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA009055LA01HU at dilution of 1:50
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FTSJ1 Polyclonal antibody
  • Uniprot No.：
    Q9UET6
  • 基因名：
    FTSJ1
  • 别名：
    CDLIV antibody; FTSJ 1 antibody; FtsJ homolog 1 (E. coli) antibody; FtsJ homolog 1 antibody; FtsJ RNA methyltransferase homolog 1 antibody; FTSJ1 antibody; JM23 antibody; Mental retardation X linked 44 antibody; Mental retardation X linked 9 antibody; MRX44 antibody; MRX9 antibody; Protein ftsJ homolog 1 antibody; Putative ribosomal RNA methyltransferase 1 antibody; RRMJ1 antibody; RRMJ1_HUMAN antibody; rRNA (uridine 2' O ) methyltransferase antibody; rRNA (uridine-2''-O-)-methyltransferase antibody; SPB1 antibody; TRM7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Putative tRNA (cytidine(32)/guanosine(34)-2\'-O)-methyltransferase protein (1-329AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FTSJ1 Antibody (CSB-PA009055LA01HU)，的标记方式是Non-conjugated。对于FTSJ1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA009055LB01HU FTSJ1 Antibody, HRP conjugated ELISA
    FITC CSB-PA009055LC01HU FTSJ1 Antibody, FITC conjugated
    Biotin CSB-PA009055LD01HU FTSJ1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.
  • 基因功能参考文献：
    1. we have provided strong evidence that human FTSJ1 is required for Cm32 and Gm34 modification of tRNAPhe. PMID: 26310293
    2. May play a role in the regulation of translation. Mutations cause X-linked mental retardation. PMID: 15162322
    3. A splice site mutation is associated with non-syndromic mental retardation in a large Belgian family PMID: 15342698
    4. A 50kb deletion at Xp11.23 including the two genes, SLC38A5 and FTSJ1 was found in 3 brothers with moderate to severe mental retardation. PMID: 17333282
    5. identified a novel FTSJ1 mutation in an X-linked mental retardation family through mutation screening of a cohort of 73 unrelated Japanese male probands with MR PMID: 18081026
    6. Results suggest a positive association between genetic variants and nonsyndromic X-linked mental retardation in young male subjects in the Chinese Han population. PMID: 18401546
    7. These findings suggest that genetic variations in FtsJ homolog 1 (E. coli) possibly influence human cognitive ability. PMID: 19012053
    8. Spb1p is a homologous yeast nucleolar protein PMID: 10648622

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  • 相关疾病：
    Mental retardation, X-linked 44 (MRX44)
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Class I-like SAM-binding methyltransferase superfamily, RNA methyltransferase RlmE family, TRM7 subfamily
  • 组织特异性：
    Found in fetal brain, lung, liver and kidney. In the adult brain, expressed in amygdala, caudate nucleus, corpus callosum, hippocampus and thalamus.
  • 数据库链接：

    HGNC: 13254

    OMIM: 300499

    KEGG: hsa:24140

    STRING: 9606.ENSP00000326948

    UniGene: Hs.23170