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FGFBP1 Antibody

  • 货号：
    CSB-PA623920ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Fibroblast growth factor-binding protein 1 antibody at 5μg/ml + Mouse skeletal muscle tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 26 kDa
      Observed band size: 26 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA623920ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA623920ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FGFBP1 Polyclonal antibody
  • Uniprot No.：
    Q14512
  • 基因名：
    FGFBP1
  • 别名：
    17 kDa HBGF-binding protein antibody; 17 kDa heparin binding growth factor binding protein antibody; 17 kDa heparin-binding growth factor-binding protein antibody; FGF binding protein 1 antibody; FGF BP antibody; FGF BP1 antibody; FGF-binding protein 1 antibody; FGF-BP antibody; FGF-BP1 antibody; FGFBP antibody; FGFBP-1 antibody; Fgfbp1 antibody; FGFP1_HUMAN antibody; Fibroblast growth factor binding protein 1 precursor antibody; Fibroblast growth factor-binding protein 1 antibody; HBp17 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Fibroblast growth factor-binding protein 1protein (24-234AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:200-1:1000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.
  • 基因功能参考文献：
    1. These findings indicate that the miR-146a-CREB3L1-FGFBP1 signaling axis plays an important role in the regulation of angiogenesis in human umbilical vein endothelial cells. PMID: 27121396
    2. Genetic polymorphism in the human FGFBP1 gene was associated with higher gene expression and an increased risk of familial Hypertension. PMID: 29158353
    3. Up-regulated Sox12 induced by FoxQ1 promotes hepatocellular carcinoma invasion and metastasis by transactivating Twist1 and FGFBP1 expression. PMID: 25704764
    4. overexpression of FGFBP1 or loss of WISP-2 expression is closely related to the metastasis, invasion and poor prognosis of gallbladder cancer. PMID: 23592278
    5. FGFBP1 associates with hypertension and that systematic analysis of signaling pathways can identify previously undescribed genetic associations. PMID: 21436287
    6. Sequence variation in FGFBP1 may contribute to variation in bone mineral density, possibly influencing osteoporosis risk. PMID: 20450993
    7. Upregulation of FGF-BP expression after injury stimulates FGF activity at the wound site, thus enhancing the process of epithelial repair. PMID: 15806171
    8. the FGF interaction domain is contained in the C terminus of FGF-BP1 PMID: 16257968
    9. FGF-BP can be rate-limiting for tumor growth and serves as an angiogenic switch molecule, and that it represents an increasingly promising target molecule in anti-tumor therapy[review] PMID: 16324873
    10. The upregulation of FGF-BP by regenerating renal tubular epithelial cells may provide a mechanism by which the regenerative and angiogenic activity of FGF-2 in renal capillaries can be modulated in children with HIV-HUS and other renal disease. PMID: 16352855
    11. KLF5 promotes breast cell survival partially through fibroblast growth factor-binding protein 1-pERK-mediated dual specificity MKP-1 protein phosphorylation and stabilization. PMID: 19411256
    12. KLF5 may promote breast cancer cell proliferation at least partially through directly activating the FGF-BP mRNA transcription. PMID: 19668233

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  • 亚细胞定位：
    Secreted, extracellular space. Cell membrane; Peripheral membrane protein.
  • 蛋白家族：
    Fibroblast growth factor-binding protein family
  • 组织特异性：
    Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo-epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carc
  • 数据库链接：

    HGNC: 19695

    OMIM: 607737

    KEGG: hsa:9982

    STRING: 9606.ENSP00000259988

    UniGene: Hs.1690