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FAAP20 Antibody

  • 货号：
    CSB-PA750774HA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA750774HA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FAAP20 Polyclonal antibody
  • Uniprot No.：
    Q6NZ36
  • 基因名：
    FAAP20
  • 别名：
    C1orf86 antibody; CA086_HUMAN antibody; Chromosome 1 open reading frame 86 antibody; FAAP20 antibody; Fanconi anemia associated protein of 20 kDa antibody; FP7162 antibody; RP11-181G12.3 antibody; Uncharacterized protein C1orf86 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Fanconi anemia core complex-associated protein 20 protein (14-179AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FAAP20 Antibody (CSB-PA750774HA01HU)，的标记方式是Non-conjugated。对于FAAP20 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA750774HB01HU FAAP20 Antibody, HRP conjugated ELISA
    FITC CSB-PA750774HC01HU FAAP20 Antibody, FITC conjugated
    Biotin CSB-PA750774HD01HU FAAP20 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1.
  • 基因功能参考文献：
    1. Data suggest Rev1 protein recognition mechanism by Fanconi anemia-associated protein 20 (FAAP20). PMID: 26318859
    2. FAAP20 contains a conserved ubiquitin-binding zinc-finger domain and binds K-63-linked ubiquitin chains in vitro. The FAAP20-UBZ domain is not required for interaction with FANCA, but is required for DNA-damage-induced chromatin loading of FANCA and the functional integrity of the Fanconi anemia pathway. PMID: 22343915
    3. FAAP20-ubiquitin interaction expands beyond the compact UBZ domain and requires the folding and interaction of the otherwise disordered C-terminal tail of FAAP20 for high-affinity binding. PMID: 25414354
    4. Data indicate that RNF8 and FAAP20 (C1orf86) are needed for efficient Fanconi anemia group D2 protein FANCD2 monoubiquitination. PMID: 22705371
    5. FAAP20 is an important player involved in the Fanconi anemia pathway PMID: 22396592

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  • 亚细胞定位：
    Nucleus. Chromosome.
  • 数据库链接：

    HGNC: 26428

    OMIM: 615183

    KEGG: hsa:199990

    STRING: 9606.ENSP00000367808

    UniGene: Hs.107101