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ELAC2 Antibody

  • 中文名称：
    ELAC2兔多克隆抗体
  • 货号：
    CSB-PA040225
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9BQ52
  • 基因名：
    ELAC2
  • 别名：
    COXPD17 antibody; elaC homolog 2 (E. coli) antibody; ElaC homolog protein 2 antibody; elaC ribonuclease Z 2 antibody; elaC, E. coli, homolog of, 2 antibody; ELAC2 antibody; ELC2 antibody; FLJ10530 antibody; FLJ36693 antibody; FLJ42848 antibody; Heredity prostate cancer protein 2 antibody; HPC2 antibody; putative prostate cancer susceptibility protein HPC2/ELAC2 antibody; Ribonuclease Z 2 antibody; Ribonuclease Z, long form antibody; Ribonuclease Z2 antibody; RNase Z 2 antibody; RNase Z2 antibody; RNase ZL antibody; RNZ2_HUMAN antibody; tRNA 3 endonuclease 2 antibody; tRNase Z (long form) antibody; tRNase Z 2 antibody; tRNase Z2 antibody; Zinc phosphodiesterase ELAC protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human RNase Z2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly.
  • 基因功能参考文献：
    1. This study describes the cardiac phenotype and outcome of ELAC2 mutation in Infantile Cardiomyopathy PMID: 28441660
    2. ELAC2 rs11545302 polymorphism was associated with PSA > 20 and rs4792311 was associated with TNM > 2. PMID: 27318894
    3. A homozygous splicing mutation in ELAC2 suggests phenotypic variability including intellectual disability with minimal cardiac involvement PMID: 27769300
    4. ELAC2 mutations cause a mitochondrial RNA processing defect associated with hypertrophic cardiomyopathy. PMID: 23849775
    5. results indicate that ELAC2 functions as a tRNase Z in human mitochondria and suggest that mt-tRNase Z preferentially cleaves molecules already processed by the proteinaceous mtRNase P PMID: 21593607
    6. ELAC2 and PTCD1 affect the 3' end processing of tRNAs. PMID: 21857155
    7. analysis of dual nuclear/mitochondrial targeting of the ELAC2 gene product by alternative translation initiation PMID: 21559454
    8. Data describe polymorphisms in the HPC/ELAC-2 and alpha 1-antitrypsin genes that correlate with human diseases in an Indian population. PMID: 20119870
    9. ELAC2 polymorphisms are associated with prostate cancer. PMID: 20231859
    10. Our findings corroborate the involvement of ELAC2, MSR1, and RNASEL in the etiology of prostate cancer even in individuals without a family history. PMID: 20086112
    11. variation in the putative prostate cancer susceptibility gene ELAC2 contributes to the elevated risk of prostate cancer in Afro-Caribbean males from Tobago PMID: 12384782
    12. Meta-analysis of associations of the Ser217Leu and Ala541Thr variants in ELAC2 (HPC2) and prostate cancer PMID: 12515253
    13. Although the Leu217 and Thr541 variants of ELAC2 are less common in Japanese than in Caucasians, both variants confer significantly increased risk of prostate cancer in Japanese. PMID: 12522685
    14. ELAC2 interacts with the gamma-tubulin complex and perturbation of ELAC2 might promote tumorigenesis through irregular cell division PMID: 12569551
    15. There is no evidence that either ELAC2 polymorphism is associated with prostate cancer or PSA level. PMID: 12783937
    16. polymorphism of the ELAC2 gene is associated with prostatic cancer risk in Japanese men PMID: 12949798
    17. When considering joint genotypes, white men homozygous for the Leu217 variant on an Ala541/Ala541 background had an increased risk of prostate cancer [odds ratio (OR)=1.84; 95% confidence interval (CI), 1.11-3.06]. PMID: 14504198
    18. ELAC2 has a role in prostate cancer PMID: 14625808
    19. Thr allele at 541 in HPC2/ELAC2 has strong significance in the predisposition of sporadic Pca in Japan. PMID: 15368467
    20. Single nucleotide polymorphisms associated with hereditary prostate cancer. PMID: 16114055
    21. candidate prostate cancer susceptibility gene ELAC2 potentiates TGF-beta/Smad-induced transcriptional responses PMID: 16636667
    22. The oncogenic role of HPC2 in human primary breast carcinomas is determined by its capacity to inhibit INK4a/ARF proteins(p16INK4a, p14ARF, or h-TERT) or to induce telomerase activity. PMID: 17145810
    23. Common SNPs and haplotypes of ELAC2 are associated with risk of aggressive prostate cancer. PMID: 18375959
    24. Changes in K(M) observed with some of the substitutions suggest contacts between tRNase Z and substrate tRNA in this region, and changes in tRNA structure provide an additional basis for interpretation of the kinetic effects.[tRNase Z] PMID: 18421255
    25. HPC2/ELAC2 and RNASEL may play a role, however minor, in prostate cancer risk among African American men. PMID: 18767027
    26. The findings reveal that 3' end processing is a limiting step for defective tRNA maturation and demonstrate that overexpression of ELAC2 can promote defective tRNA 3' processing in vivo. PMID: 19555350
    27. The present data suggest the possibility that human cytosolic tRNase ZL modulates gene expression through a subset of microRNAs in the cells. PMID: 19751732
    28. Observational study and meta-analysis of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 15824169
    29. ELAC2 harbors mutations (including a frameshift and a nonconservative missense change) that segregate with prostate cancer in two Utah pedigrees PMID: 11175785

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  • 相关疾病：
    Prostate cancer, hereditary, 2 (HPC2); Combined oxidative phosphorylation deficiency 17 (COXPD17)
  • 亚细胞定位：
    Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid. Nucleus. Note=Mainly mitochondrial.
  • 蛋白家族：
    RNase Z family
  • 组织特异性：
    Widely expressed. Highly expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, testis and ovary. Weakly expressed in brain, lung, spleen, thymus, prostate, small intestine, colon and leukocytes.
  • 数据库链接：

    HGNC: 14198

    OMIM: 176807

    KEGG: hsa:60528

    STRING: 9606.ENSP00000337445

    UniGene: Hs.434232