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EID3 Antibody

  • 中文名称：
    EID3兔多克隆抗体
  • 货号：
    CSB-PA693996
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA693996(EID3 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA693996(EID3 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse kidney tissue, Primary antibody: CSB-PA693996(EID3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

产品详情

  • Uniprot No.：
    Q8N140
  • 基因名：
    EID3
  • 别名：
    E1A-like inhibitor of differentiation 3 antibody; EID 3 antibody; EID-1-like inhibitor of differentiation 3 antibody; EID-3 antibody; EID3 antibody; EID3_HUMAN antibody; EP300 interacting inhibitor of differentiation 3 antibody; EP300-interacting inhibitor of differentiation 3 antibody; FLJ25832 antibody; Non-SMC element 4; S. cerevisiae; homolog of; B antibody; Non-structural maintenance of chromosomes element 4 homolog B antibody; NSE4B antibody; NSMCE4B antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human EID3
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components.; Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors.
  • 基因功能参考文献：
    1. Knockdown of EID3 by specific shRNA attenuated BMS-345541 -induced radiosensitization in MCF-7 cells. PMID: 30114644
    2. These findings indicated a novel mechanism by which EID3, a p300 acetyltransferase inhibitor, could directly affect DNMT3A, this enzyme possesses dual methylation and demethylation abilities. PMID: 28074931
    3. EID3 acts as an inhibitor of CBP/p300-dependent transcription in a tissue-specific manner. PMID: 15987788
  • 亚细胞定位：
    Nucleus. Cytoplasm. Chromosome, telomere.
  • 蛋白家族：
    NSE4 family
  • 组织特异性：
    Highly expressed in testis.
  • 数据库链接：

    HGNC: 32961

    OMIM: 612986

    KEGG: hsa:493861

    STRING: 9606.ENSP00000435619

    UniGene: Hs.659857